Effects of differences in serum total homocysteine, folate, and vitamin B12 on cognitive impairment in stroke patients

被引：20

作者：

Jiang B. ^{[1
]}

Chen Y. ^{[1
]}

Yao G. ^{[1
]}

Yao C. ^{[1
]}

Zhao H. ^{[1
]}

Jia X. ^{[1
]}

Zhang Y. ^{[1
]}

Ge J. ^{[1
]}

Qiu E. ^{[1
]}

Ding C. ^{[1
]}

机构：

[1] Department of Neuromedical Center, The First Hospital Affiliated to the Chinese PLA General Hospital, 51 Fucheng Avenue, Beijing, Haidian District

来源：

BMC Neurology | / 14卷 / 1期

关键词：

Cerebrovascular disorder; Cognitive impairment; Event related potentials P300; Homocysteine; Neuropsychology;

D O I：

10.1186/s12883-014-0217-9

中图分类号：

学科分类号：

摘要：

Background: Vascular cognitive impairment-no dementia (VCIND) refers to the early or mild cognitive impairment induced by cerebral vascular injury. Research shows that serum total homocysteine (tHcy) level is an independent risk factor for cerebral vascular disease and may be closely related to cognitive function. Current studies on the tHcy level in VCIND patients are limited, and the relationship of tHcy with cognitive function remains unclear. This study aims to investigate the tHcy levels in patients with VCIND and to determine their correlation with cognitive function, as well as to provide useful clues for preventing and treating VCIND. Methods: The tHcy, folate, and vitamin B12 levels in 82 patients with VCIND were reviewed retrospectively and compared with those of 80 stroke patients without cognitive impairment and 69 healthy controls by using the Montreal Cognitive Assessment (MoCA) scale and the event-related potential P300 to evaluate cognitive function. Results: The tHcy levels in the VCIND group were higher than those in the other two groups, whereas the folate and Vitamin B12 levels in the VCIND group were lower than those of the other two groups. The tHcy levels in the stroke group were higher than those in the control group, and the folate and vitamin B12 levels in the stroke group were lower than those in the control group. The patients in the VCIND group with high tHcy exhibited lower MoCA scores and prolonged P300 latency than those in with normal tHcy. Correlation analysis showed that tHcy level is positively correlated with P300 latency period and negatively correlated with MoCA score. Conclusion: The tHcy levels were significantly higher and the vitamin B12 and folate levels were significantly lower in the patients with VCIND than those in the other groups. The high tHcy levels in the VCIND patients may be correlated with impaired cognitive function. © 2014 Jiang et al.

引用

共 29 条

[1]

Moorhouse P., Rockwood K., Vascular cognitive impairment: current concepts and clinical developments, Lancet Neurol, 7, pp. 246-255, (2008)

[2]

Serrano S., Domingo J., Rodriguez-Garcia E., Castro M.D., Ser T., Frequency of cognitive impairment without dementia in patients with stroke: a two-year follow-up study, Stroke, 38, pp. 105-110, (2007)

[3]

Stephan B.C., Matthews F.E., Khaw K.T., Dufouil C., Brayne C., Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND), Alzheimers Res Ther, 1, (2009)

[4]

Manolescu B.N., Oprea E., Farcasanu I.C., Berteanu M., Cercasov C., Homocysteine and vitamin therapy in stroke prevention and treatment: a review, Acta Biochim Pol, 57, pp. 467-477, (2010)

[5]

Sala I., Belen Sanchez-Saudinos M., Molina-Porcel L., Lazaro E., Gich I., Clarimon J., Blanco-Vaca F., Blesa R., Gomez-Isla T., Lleo A., Homocysteine and cognitive impairment. relation with diagnosis and neuropsychological performance, Dement Geriatr Cogn Disord, 26, pp. 506-512, (2008)

[6]

Roman G.C., Sachdev P., Royall D.R., Bullock R.A., Orgogozo J.M., Lopez-Pousa S., Arizaga R., Wallin A., Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia, J Neurol Sci, 226, pp. 81-87, (2004)

[7]

Rockwood K., Howard K., MacKnight C., Darvesh S., Spectrum of disease in Vascular cognitive impairment, Neuroepidemiology, 18, pp. 248-254, (1999)

[8]

European stroke initiative recommendations for stroke management-update 2003, Cerebrovasc Dis, 16, pp. 311-337, (2003)

[9]

Karunaratne S., Hanwella R., Silva V., Validation of the sinhala version of the montreal cognitive assessment in screening for dementia, Ceylon Med J, 56, pp. 147-153, (2011)

[10]

Refsum H., Smith A.D., Ueland P.M., Nexo E., Clarke R., McPartlin J., Johnston C., Engbaek F., Schneede J., McPartlin C., Scott J.M., Facts and recommendations about total homocysteine determinations: an expert opinion, Clin Chem, 50, pp. 3-32, (2004)

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