Cooperative Type of Platelet Hypersensitivity to ADP

被引：0

作者：

E. Yu. Shabanova

I. V. Mindukshev

E. A. Malakhovskaya

E. V. Vivulanets

N. N. Petrishchev

A. I. Krivchenko

机构：

[1] I. P. Pavlov St. Petersburg State Medical University,Department of Pathophysiology

[2] Russian Academy of Sciences,Laboratory for Physiology of Respiration, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry

来源：

Bulletin of Experimental Biology and Medicine | 2005年 / 140卷

关键词：

cooperativeness; hypersensitivity; purine receptors; gestosis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We found that gestosis is associated with platelet hypersensitivity to ADP. Cell P2X1 receptors exhibited a positive cooperative response to ADP (EC50=10.88±3.70 nM, Hill constant n=2.59±0.50 rel. units). Cooperative binding of ADP to platelet P2X1 receptors was also observed during incubation of cells from pregnant women with isosorbide dinitrate.

引用

页码：282 / 284

页数：2

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