Cooperative Type of Platelet Hypersensitivity to ADP

被引：0
|
作者：
E. Yu. Shabanova
I. V. Mindukshev
E. A. Malakhovskaya
E. V. Vivulanets
N. N. Petrishchev
A. I. Krivchenko
机构：
[1] I. P. Pavlov St. Petersburg State Medical University,Department of Pathophysiology
[2] Russian Academy of Sciences,Laboratory for Physiology of Respiration, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry
来源：
Bulletin of Experimental Biology and Medicine | 2005年 / 140卷
关键词：
cooperativeness; hypersensitivity; purine receptors; gestosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We found that gestosis is associated with platelet hypersensitivity to ADP. Cell P2X1 receptors exhibited a positive cooperative response to ADP (EC50=10.88±3.70 nM, Hill constant n=2.59±0.50 rel. units). Cooperative binding of ADP to platelet P2X1 receptors was also observed during incubation of cells from pregnant women with isosorbide dinitrate.
引用
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页码：282 / 284
页数：2
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