The synthesis of triterpenic amides on the basis of 2,3-seco-1-cyano-19β,28-epoxy-18α-oleane-3-oic acid

被引：0
作者：
I. A. Tolmacheva
E. V. Igosheva
V. V. Grishko
O. S. Zhukova
G. K. Gerasimova
机构：
[1] Russian Academy of Sciences,Institute of Technical Chemistry, Ural Division
[2] Perm State University,Blokhin Cancer Research Center
[3] Russian Academy of Medical Sciences,undefined
来源：
Russian Journal of Bioorganic Chemistry | 2010年 / 36卷
关键词：
2,3-seco-triterpenoids; betulin; allobetulon; amides; amino acids; cytotoxic activity; melanoma;
D O I：
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中图分类号：
学科分类号：
摘要：
Novel 2,3-seco-triterpenic amides were prepared by the interaction of the chloride of 1-cyano-19β,28-epoxy-18α-oleane-3-oic acid with primary amines and synthetic and biogenic amino acids. A cytotoxic triterpenic conjugate with a residue of the ethyl ester of β-alanine was found among the synthesized nitrogen-containing derivatives. Treatment with this conjugate in a concentration of 100 μM resulted in the 45.5% survival of melanoma cells in the medium.
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页码：377 / 382
页数：5
相关论文
共 48 条
  • [1] Lontsi D.(1989)undefined J. Nat. Prod. 52 52-56
  • [2] Sondengam B.L.(2008)undefined J. Nat. Prod. 71 1352-1357
  • [3] Ayafor J.F.(2008)undefined Phytochemistry 69 1875-1879
  • [4] Chen I.-H.(2009)undefined Bioorg. Med. Chem. 17 3003-3010
  • [5] Du Y.-Ch.(2004)undefined J. Nat. Prod. 67 1100-1105
  • [6] Lu M.-Ch.(2010)undefined Bioorg. Khim. 36 259-264
  • [7] Lin A.-Sh.(1988)undefined Cancer Res. 48 589-601
  • [8] Hsieh P.-W.(2001)undefined Bioorg. Med. Chem. Lett. 11 2405-2408
  • [9] Wu Ch.-Ch.(2004)undefined Med. Res. Rev. 24 90-114
  • [10] Chen Sh.-L.(2006)undefined Eur. J. Pharm. Sci. 29 1-13
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