Purpose of ReviewThis article provides a clue for the anticancer and antibacterial, antifungal, antiviral, and antioxidant use of Ag, Au, and ZnO nanoparticles (NPs) highlighting their biological activities, potential applications, and protection.Recent FindingsRemedy from the menace of bacterial resistance against antibiotic drugs seems to be the plant-mediated biosynthesized NPs. They are cost-effective, greatly biocompatible, and eco-friendly with varieties of potential applications such as antimicrobials, antifungal, antiobesity, and wound healing. Ag, Au, and ZnO NPs with no adverse effects have been considered for the purpose as disinfectant and antimicrobial fabrics. SEM equipped with EDX study confirmed the incorporation of the NPs on the fabrics. The HRTEM study realizes the attachment of NPs in spherical shapes.SummaryThe effect of the antimicrobial application and wound healing potential of the nanoparticles and nanofabrics is explored on the various pathogenic microbes.