Vitamin D supplementation to patients with frequent respiratory tract infections: A post hoc analysis of a randomized and placebo-controlled trial

被引：18
作者：
Bergman P. [1 ]
Norlin A.-C. [2 ]
Hansen S. [3 ]
Björkhem-Bergman L. [1 ]
机构：
[1] Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm
[2] Division of Clincal Immunology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm
[3] Infectious Disease Clinic, Karolinska University Hospital, Stockholm
来源：
BMC Research Notes | / 8卷 / 1期
关键词：
Immunodeficiency; Infections; Randomized controlled trial; Respiratory tract infections; Supplementation; Vitamin D;
D O I：
10.1186/s13104-015-1378-3
中图分类号：
学科分类号：
摘要：
Background: Vitamin D is considered to be important for a healthy immune system. The aim of this study was to test the hypothesis that vitamin D supplementation reduces number of respiratory tract infections (RTIs) and prolong the time to the first RTI in adult patients with frequent RTIs. Methods: We performed a post hoc analysis of a randomized, placebo-controlled and double-blinded study, where adult patients with a high burden of RTIs were randomized to placebo or vitamin D (4000 IE/day for 1 year, n = 124 in the per protocol cohort presented here). Results: Vitamin D supplementation increased the probability to stay free of RTI during the study year (RR 0.64, 95 % CI 0.43-0.94). Further, the total number of RTIs was also reduced in the vitamin D-group (86 RTIs) versus placebo (120 RTIs; p = 0.05). Finally, the time to the first RTI was significantly extended in the vitamin D-group (HR 1.68, 95 % CI 1.03-2.68, p = 0.0376). Conclusion: Vitamin D supplementation was found to significantly increase the probability of staying infection free during the study period. This finding further supports the notion that vitamin D-status should be monitored in adult patients with frequent RTIs and suggests that selected patients with vitamin D deficiency are supplemented. This could be a safe and cheap way to reduce RTIs and improve health in this vulnerable patient population. The original trial was registered at http://www.clinicaltrials.gov (NCT01131858). © 2015 Bergman et al.
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