Cytokine Responses to Specific Immunotherapy in House Dust Mite-Induced Allergic Rhinitis Patients

被引：0
作者：
Hong Li
Enxiu Xu
Mingqiang He
机构：
[1] Provincial Hospital affiliated to Shandong University,Department of Otolaryngology
[2] Provincial Hospital affiliated to Shandong University,Head and Neck Surgery
来源：
Inflammation | 2015年 / 38卷
关键词：
sublingual immunotherapy; IL-17; house dust mite; allergic rhinitis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Allergen-specific immunotherapy is the only immunomodulatory treatment that may alter the natural course of allergic disease. However, cytokine responses accompanying sublingual immunotherapy (SLIT) responder phenotypes have not been fully understood. Herein, we examined the level of crucial plasma cytokines during SLIT and evaluated whether their changes correlated to symptom scores. We observed that the levels of interleukin (IL)-17 and complement components C3a and C5a as well as IL-4 at year 3 of SLIT were significantly decreased than those at baseline. In contrast, there was no significant difference in the levels of IL-5, IL-13, and interferon (IFN)-γ. Notably, a significant positive correlation was found between the levels of IL-17 and the symptom scores at year 3. These results suggest that IL-17 could be considered a potential biomarker for the therapeutic effect of SLIT in allergic rhinitis caused by house dust mite.
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页码：2216 / 2223
页数：7
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