Design and radio-synthesis of somatostatin receptors targeted 68Ga-DOTA-Benereotide for non-invasive PET imaging

被引：0
作者：
Fei Liu
Hua Zhu
Chuangui Li
Xinfeng Lin
Chiyi Xiong
Chun Li
Zhi Yang
机构：
[1] Peking University Cancer Hospital & Institute,Key Laboratory of Carcinogenesis and Translational Research, Department of Nuclear Medicine
[2] First Affiliated Hospital of Hebei North University,Department of Radiology
[3] The University of Texas MD Anderson Cancer Center,Department of Cancer Systems Imaging
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2016年 / 307卷
关键词：
Somatostatin receptors; Benerotide peptide; Micro-PET imaging; Ga tracer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Here we reported the synthesis, radiolabeling and evaluation of a novel positron emission tomography (PET) tracer DOTA-Benerotide labeled with 68Ga with potential application in SSTR1,2,3,5 positive tumors for PET imaging. Radiolabeling of DOTA-Benerotide with 68Ga achieved its highest efficiency at pH 3.5 and 100 °C for 20 min. It also showed excellent in vitro stability in different buffers. Micro-PET imaging of human colorectal adenocarcinoma tumor cell (HT-29) bearing mice clearly delineated tumors at 4 h after tail vein injection of 68Ga-DOTA-Benerotide tracer. Further studies are needed to identify the mechanism of cell/organ uptake of this new SSTR PET imaging tracer.
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页码：1069 / 1075
页数：6
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