The causal relationship between serum metabolites and acne vulgaris: a Mendelian randomization study

被引：7

作者：

Wang, Xiaoyun ^{[1
]}

Wu, Yujia ^{[1
]}

Zhao, Pengfei ^{[1
]}

Wang, Xinren ^{[1
]}

Wu, Wenjuan ^{[2
]}

Yang, Jiankang ^{[1
]}

机构：

[1] Dali Univ, Sch Basic Med Sci, Dali, Peoples R China

[2] Kunming Med Univ, Dept Dermatol & Venereol, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Acne vulgaris; Serum metabolites; Mendelian randomization; Causal inference; Genome-wide association;

D O I：

10.1038/s41598-024-61850-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In individuals with acne vulgaris, alterations occur in serum metabolite composition, yet the exact causal link between these metabolites and acne development remains elusive. Using genome-wide association datasets, we performed bidirectional Mendelian randomization (MR) to investigate the potential causal relationship between 309 serum metabolites and acne vulgaris. We performed sensitivity analysis to evaluate the presence of heterogeneity and pleiotropy. Forward MR analysis found 14 serum metabolites significantly associated with acne vulgaris, and reverse MR analysis found no significant association between acne vulgaris and these serum metabolites. Through validation using data from the FinnGen database of acne vulgaris studies, we found a conclusive and significant correlation between stearoylcarnitine and acne vulgaris. This provides new evidence in the search for new targets for the treatment of acne vulgaris.

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页数：9

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