Endothelial cell heterogeneity and atherosclerosis

被引：31
作者：
Aird W.C. [1 ]
机构：
[1] Division of Molecular and Vascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston
来源：
Current Atherosclerosis Reports | 2006年 / 8卷 / 1期
关键词：
Endothelial Cell; Vascular Tree; Tissue Factor Pathway Inhibitor; Endothelial Cell Activation; Vasomotor Tone;
D O I：
10.1007/s11883-006-0067-z
中图分类号：
学科分类号：
摘要：
Vascular diseases are the most common causes of morbidity and mortality in the Western world. These conditions, whether they involve small and/ or large vessels, invariably manifest as localized lesions within the vascular tree. For example, atherosclerosis preferentially affects arteries at branch points, the outer wall of bifurcations, and the inner walls of curvatures. An important question is how systemic alterations in blood-borne factors (eg, those associated with cardiac risk factors) result in focal vasculopathy. A clue to the answer lies in the complex spatial and temporal dynamics of the endothelium. The goal of this review is to highlight concepts of endothelial cell heterogeneity and to apply these principles to an understanding of the pathogenesis, diagnosis, and treatment of atherosclerosis. Copyright © 2006 by Current Science Inc.
引用
收藏
页码：69 / 75
页数：6
相关论文
共 46 条
[1]  
Aird W.C., Endothelium as an organ system, Crit Care Med, 32, 5 SUPPL., (2004)
[2]  
Aird W.C., Spatial and temporal dynamics of the endothelium, J Thromb Haemost, 3, pp. 1392-1406, (2005)
[3]  
Cines D.B., Pollak E.S., Buck C.A., Et al., Endothelial cells in physiology and in the pathophysiology of vascular disorders, Blood, 91, pp. 3527-3561, (1998)
[4]  
Aird W.C., Endothelial cell heterogeneity, Crit Care Med, 31, 4 SUPPL., (2003)
[5]  
Oh P., Li Y., Yu J., Et al., Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy, Nature, 429, pp. 629-635, (2004)
[6]  
Trepel M., Arap W., Pasqualini R., In vivo phage display and vascular heterogeneity: Implications for targeted medicine, Curr Opin Chem Biol, 6, pp. 399-404, (2002)
[7]  
Rosenberg R.D., Aird W.C., Vascular-bed-specific hemostasis and hypercoagulable states, N Engl J Med, 340, pp. 1555-1564, (1999)
[8]  
Aird W.C., Vascular bed-specific hemostasis: Role of endothelium in sepsis pathogenesis, Crit Care Med, 29, (2001)
[9]  
Aird W.C., Endothelial cell heterogeneity: A case for nature and nurture, Blood, 103, pp. 3994-3995, (2004)
[10]  
Pober J.S., Gimbrone Jr. M.A., Expression of Ia-like antigens by human vascular endothelial cells is inducible in vitro: Demonstration by monoclonal antibody binding and immunoprecipitation, Proc Natl Acad Sci U S A, 79, pp. 6641-6645, (1982)
12345