High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae

被引：0
作者：
Hun-Goo Lee
Hyo-Soo Lee
Sang-Hoon Jeon
Tae-Hoon Chung
Young-Sung Lim
Won-Ki Huh
机构：
[1] Dong-a Seetech Research Institute,Department of Bioinformatics
[2] Seoul National University,School of Biological Sciences and Research Center for Functional Cellulomics, Institute of Microbiology
[3] Computational Biology Division,undefined
[4] TGEN,undefined
来源：
Genome Biology | / 9卷
关键词：
Additional Data File; Transcriptional Regulatory Network; Nucleosome Occupancy; Nitrogen Depletion; Cell Cycle Condition;
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摘要：
We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.
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