Irisin/PGC-1α/FNDC5 pathway in Parkinson’s disease: truth under the throes

被引：0
作者：
Naif H. Ali
Nourah Ahmad Alhamdan
Hayder M. Al-kuraishy
Ali I. Al-Gareeb
Engy Elekhnawy
Gaber El-Saber Batiha
机构：
[1] Najran University,Department of Internal Medicine, Medical College
[2] Qassim University,Department of Medicine, Unaizah College of Medicine and Medical Sciences
[3] Al-Mustansiriyah University,Department of Pharmacology, Toxicology and Medicine, College of Medicine
[4] Tanta University,Pharmaceutical Microbiology Department, Faculty of Pharmacy
[5] Damanhour University,Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2024年 / 397卷
关键词：
Parkinson’s disease; Irisin hormone; Neuroinflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Parkinson’s disease (PD) is considered one of the most common neurodegenerative brain diseases which involves the deposition of α-synuclein. Irisin hormone, a newly discovered adipokine, has a valuable role in diverse neurodegenerative diseases. Therefore, this review aims to elucidate the possible role of the irisin hormone in PD neuropathology. Irisin hormone has a neuroprotective effect against the development and progression of various neurodegenerative disorders by increasing the expression of brain-derived neurotrophic factor (BDNF). Irisin hormone has anti-inflammatory, anti-apoptotic, and anti-oxidative impacts, thereby reducing the expression of the pro-inflammatory cytokines and the progression of neuroinflammation. Irisin-induced PGC-1α could potentially prevent α-synuclein-induced dopaminergic injury, neuroinflammation, and neurotoxicity in PD. Inhibition of NF-κB by irisin improves PGC-1α and FNDC5 signaling pathway with subsequent attenuation of PD neuropathology. Therefore, the irisin/PGC-1α/FNDC5 pathway could prevent dopaminergic neuronal injury. In conclusion, the irisin hormone has a neuroprotective effect through its anti-inflammatory and antioxidant impacts with the amelioration of brain BDNF levels. Further preclinical and clinical studies are recommended in this regard.
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页码：1985 / 1995
页数：10
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