Baseline antibody profiles predict toxicity in melanoma patients treated with immune checkpoint inhibitors

被引:0
作者
Michael F. Gowen
Keith M. Giles
Danny Simpson
Jeremy Tchack
Hua Zhou
Una Moran
Zarmeena Dawood
Anna C. Pavlick
Shaohui Hu
Melissa A. Wilson
Hua Zhong
Michelle Krogsgaard
Tomas Kirchhoff
Iman Osman
机构
[1] New York University School of Medicine,The Ronald O. Perelman Department of Dermatology
[2] New York University School of Medicine,Applied Bioinformatics Core
[3] New York University School of Medicine,Division of Hematology & Oncology, Perlmutter Cancer Center
[4] New York University School of Medicine,Division of Epidemiology
[5] New York University School of Medicine,Department of Population Health
[6] New York University School of Medicine,Department of Pathology
[7] CDI Laboratories,Department of Medicine
[8] New York University School of Medicine,undefined
来源
Journal of Translational Medicine | / 16卷
关键词
Melanoma; Immunotherapy; Antibodies; Toxicity; Biomarker;
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[1]  
Franklin C(2017)Immunotherapy in melanoma: recent advances and future directions Eur J Surg Oncol 43 604-611
[2]  
Livingstone E(2016)Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial Lancet Oncol 17 1558-1568
[3]  
Roesch A(2016)Immune-related adverse events associated with immune checkpoint inhibitors BioDrugs 30 571-584
[4]  
Schilling B(2015)Combined nivolumab and ipilimumab or monotherapy in untreated melanoma N Engl J Med 373 23-34
[5]  
Schadendorf D(2016)Toxicity management of immunotherapy for patients with metastatic melanoma Ann Transl Med 4 272-1855
[6]  
Hodi FS(2016)Prolonged survival in stage iii melanoma with ipilimumab adjuvant therapy N Engl J Med 375 1845-e551
[7]  
Chesney J(2017)Adjuvant nivolumab versus ipilimumab in resected stage iii or iv melanoma N Engl J Med 17 e542-11924
[8]  
Pavlick AC(2016)Predictive biomarkers for checkpoint inhibitor-based immunotherapy Lancet Oncol 8 592-574
[9]  
Robert C(2017)Predictors of responses to immune checkpoint blockade in advanced melanoma Nat Commun 11 75-1206
[10]  
Grossmann KF(2013)Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events J Transl Med 113 11919-43