Atherosclerosis of the descending aorta predicts cardiovascular events: A transesophageal echocardiography study

被引：15
作者：
Varga A. [1 ]
Gruber N. [1 ]
Forster T. [1 ]
Piros G. [1 ]
Havasi K. [1 ]
Jebelovszki É. [1 ]
Csanády M. [1 ]
机构：
[1] 2nd Department of Medicine, Cardiology Center, University of Sciences, Szeged
来源：
Cardiovascular Ultrasound | / 2卷 / 1期
关键词：
Coronary Flow Reserve; Transesophageal Echocardiography; Suspected Coronary Artery Disease; Future Cardiovascular Event; Fatal Stroke;
D O I：
10.1186/1476-7120-2-21
中图分类号：
学科分类号：
摘要：
Purpose: Previous studies have shown that atherosclerosis of the descending aorta detected by transesophageal echocardiography (TEE) is a good marker of coexisting coronary artery disease. The aim of our study was to evaluate whether the presence of atherosclerosis on the descending aorta during TEE has any prognostic impact in predicting cardiovascular events. Material and Methods: The study group consisted of 238 consecutive in-hospital patients referred for TEE testing (135 males, 103 females, mean age 58 +/- 11 years) with a follow up of 24 months. The atherosclerotic lesions of the descending aorta were scored from 0 (no atherosclerosis) to 3 (plaque >5 mm and/or "complex" plaque with ulcerated or mobile parts). Results: Atherosclerosis was observed in 102 patients, (grade 3 in 16, and grade 2 in 86 patients) whereas 136 patients only had an intimal thickening or normal intimal surface. There were 57 cardiovascular events in the follow-up period. The number of events was higher in the 102 patients with (n = 34) than in the 136 patients without atherosclerosis (n = 23, p < 0.01). The frequency of events was in close correlation with the severity of the atherosclerosis of the descending aorta. Fifty percent of the patients with grade 3 experienced cardiovascular events. Excluding patients with subsequent revascularization, the multivariate analysis only left ventricular function with EF < 40% (HR 3.0, CI 1.3-7.1) and TEE atherosclerotic plaque >=2 (HR 2.4, CI 1.0-5.5) predicted hard cardiovascular events. Conclusion: Atherosclerosis of the descending aorta observed during transesophageal echocardiography is a useful predictor of cardiovascular events. © 2004 Varga et al; licensee BioMed Central Ltd.
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  • [1] Ambrose J.A., Fuster V., Can we predict future acute coronary events in patients with stable coronary artery disease?, JAMA, 277, pp. 343-344, (1997)
  • [2] Fazio G.P., Redberg R., Winslow T., Schiller N.B., Transesophageal echocardiography detected atherosclerotic aortic plaque is marker for coronary artery disease, J Am Coll Cardiol, 21, pp. 144-150, (1993)
  • [3] Tribouilloy C., Shen W.F., Peltier M., Lesbre J.P., Noninvasive prediction of coronary artery disease by transesophageal echocardiographic detection of thoracic aortic plaque in valvular heart disease, Am J Cardiol, 74, pp. 258-260, (1994)
  • [4] Parthenakis F., Skalidis E., Simantirakis E., Kounali D., Vardas P., Nihoyannopoulos P., Absence of atherosclerotic lesions in the thoracic aorta indicates absence of significant coronary artery disease, Am J Cardiol, 77, pp. 1118-1121, (1996)
  • [5] Matsumura Y., Takata J., Yabe T., Furuno T., Chikamori T., Doi Y.L., Atherosclerotic aortic plaque detected by transesophageal echocardiography: Its significance and limitation as a marker for coronary artery disease in the elderly, Chest, 112, pp. 81-86, (1997)
  • [6] Tribouilloy C., Peltier M., Colas L., Rida Z., Rey J.L., Lesbre J.P., Multiplane transesophageal echocardiographic absence of thoracic aortic plaque is a powerful predictor for absence of significant coronary artery disease in valvular patients, even in elderly. A large prospective study, Eur Heart J, 18, pp. 1478-1483, (1997)
  • [7] Tribouilloy C., Peltier M., Senni M., Colas L., Rey J.L., Lesbre J.P., Multiplane transesophageal echocardiographic detection of thoracic aortic plaque is a marker for coronary artery disease in women, Int J Cardiol, 61, pp. 269-275, (1997)
  • [8] Tribouilloy C., Peltier M., Rey J.L., Ruiz V., Lesbre J.P., Use of transesophageal echocardiography to predict significant coronary artery disease in aortic stenosis, Chest, 113, pp. 671-675, (1998)
  • [9] Khoury Z., Gottlieb S., Stern S., Keren A., Frequency and distribution of atherosclerotic plaques in the thoracic aorta as determined by transesophageal echocardiography in patients with coronary artery disease, Am J Cardiol, 79, pp. 23-27, (1997)
  • [10] Cohen A., Tzourio C., Bertrand B., Chauvel C., Bousser M.G., Amarenco P., Aortic plaque morphology and vascular events: A follow-up study in patients with ischemic stroke, Circulation, 96, pp. 3838-3841, (1997)
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