Synthesis and hydrazinolysis of β-(1,3,4-oxadiazol-2-yl)pyridines

被引：0
|
作者：
O. U. Nesterova
A. S. Pugachova
M. V. Voevudsky
O. V. Krischik
V. I. Musatov
机构：
[1] O. Gonchar Dnepropetrovsk National University,
[2] Ukrainian State University of Chemical Engineering,undefined
[3] Institute for Single Crystals,undefined
[4] National Academy of Sciences of Ukraine,undefined
来源：
Chemistry of Heterocyclic Compounds | 2011年 / 46卷
关键词：
hydrazide; hydrazine; nicotinic acid; 1,3,4-oxadiazole; aromatic acid chlorides;
D O I：
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摘要：
Cyclization of the hydrazide of 5-ethoxycarbonyl-2,6-dimethylpyridine-3-carboxylic acid by acylation with aromatic or aliphatic acid chlorides with subsequent boiling in POCl3 or heating in orthoformic acid gave the corresponding ethyl 2,6-dimethyl-5-(5-R-1,3,4-oxadiazol-2-yl)pyridine-3-carboxylate. The cyclization of the reaction products with hydrazine hydrate has been studied. Cyclization of the dihydrazide of 2,6-dimethyl-3,5-pyridinedicarboxylic acid under analogous conditions gave only 3,5-bis-(5-R-1,3,4-oxadiazol-2-yl)-2,6-dimethylpyridines, containing R = 2-FC6H4, H.
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页码：1520 / 1526
页数：6
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