Primary esophageal CD30-positive ALK-positive anaplastic large cell lymphoma: A case report and literature review

被引：11

作者：

Wu N. ^{[1
]}

Pang L. ^{[1
]}

Chen Z. ^{[1
]}

Wang Y. ^{[1
]}

Ma Q. ^{[1
]}

Chen G. ^{[1
]}

Chen J. ^{[1
]}

Huang J. ^{[1
]}

机构：

[1] Department of Cardiothoracic Surgery, Huashan Hospital, Fudan University

来源：

Journal of Gastrointestinal Cancer | 2011年 / 42卷 / 1期

关键词：

ALK-positive; anaplastic large cell lymphoma; CD30-positive; esophageal lymphoma;

D O I：

10.1007/s12029-010-9147-y

中图分类号：

学科分类号：

摘要：

Purpose: To introduce a case of primary esophageal CD30-positive ALK-positive anaplastic large cell lymphoma (ALCL) and discuss its diagnosis and treatment. Methods: Esophagectomy was done for a 37-year-old male with a submucosal lesion after a frozen section failed to give a definite diagnosis. Samples were sent for hematoxylin-eosin staining and immunohistochemical analysis. Six cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy were given and the patient was followed up. Results: The operation was uneventful. Postoperative pathologic and immunohistochemical examination yielded a diagnosis of primary CD30-positive and ALK-positive ALCL of the esophagus. The patient was in complete remission at the 14-month follow-up. Conclusions: ALCL of the esophagus should be considered in the differential diagnosis of esophageal submucosal lesions. Biopsy through either esophagoscopy or surgical exploration, chemotherapy, and radiotherapy can be chosen for long-term survival. © 2010 Springer Science+Business Media, LLC.

引用

页码：57 / 60

页数：3

共 11 条

[1]

Stein H., Mason D.Y., Gerdes J., The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells, Blood, 66, 4, pp. 848-858, (1985)

[2]

Delsol G., Ralfkiaer E., Sein H., Et al., Anaplastic large cell lymphoma, Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumours, pp. 230-235, (2001)

[3]

Herrmann R., Panahon A.M., Barcos M.P., Gastrointestinal involvement in non-Hodgkin's lymphoma, Cancer, 46, 1, pp. 215-222, (1980)

[4]

Rosenberg S.A., Diamond H.D., Jaslowitz B., Et al., Lymphosarcoma: A review of 1269 cases, Medicine (Baltimore), 40, pp. 31-83, (1961)

[5]

Pearson J.M., Borg-Grech A., Primary Ki-1 (CD30)-positive, large cell, anaplastic lymphoma of the esophagus, Cancer, 68, pp. 418-421, (1991)

[6]

Ross C.W., Hanson C.A., Schnitzer B., CD30 (Ki-1)-positive, anaplastic large cell lymphoma mimicking gastrointestinal carcinoma, Cancer, 70, pp. 2517-2523, (1992)

[7]

Yaakup H., Sagap I., Fadilah S.A.W., Primary oesophageal Ki (CD30)-positive ALK+ anaplastic large cell lymphoma of T-cell phenotype, Singapore Med J, 49, pp. 289-292, (2008)

[8]

Doki T., Hamada S., Murayama H., Primary malignant lymphoma of the esophagus. A case report, Endoscopy, 16, 5, pp. 189-192, (1984)

[9]

Stein H., Foss H.D., Durkop H., Et al., CD30+ anaplastic large cell lymphoma: A review of its histopathologic, genetic, and clinical features, Blood, 96, pp. 3681-3695, (2000)

[10]

Thompson M.A., Stumph J., Henrickson S.E., Rosenwald A., Wang Q., Olson S., Brandt S.J., Roberts J., Zhang X., Shyr Y., Kinney M.C., Differential gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas, Human Pathology, 36, 5, pp. 494-504, (2005)

← 1 2 →