Global Properties of SIR and SEIR Epidemic Models with Multiple Parallel Infectious Stages

被引:100
作者
Korobeinikov, Andrei [1 ]
机构
[1] Univ Limerick, Dept Math & Stat, MACSI, Limerick, Ireland
基金
爱尔兰科学基金会;
关键词
Infectious disease; Mass-action; Endemic equilibrium state; Global stability; Direct Lyapunov method; Lyapunov function; NONLINEAR INCIDENCE; LYAPUNOV FUNCTIONS; DISEASE MODELS; STABILITY; DYNAMICS; TRANSMISSION;
D O I
10.1007/s11538-008-9352-z
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We consider global properties of compartment SIR and SEIR models of infectious diseases, where there are several parallel infective stages. For instance, such a situation may arise if a fraction of the infected are detected and treated, while the rest of the infected remains undetected and untreated. We assume that the horizontal transmission is governed by the standard bilinear incidence rate. The direct Lyapunov method enables us to prove that the considered models are globally stable: There is always a globally asymptotically stable equilibrium state. Depending on the value of the basic reproduction number R (0), this state can be either endemic (R (0)> 1), or infection-free (R (0)a parts per thousand currency sign1).
引用
收藏
页码:75 / 83
页数:9
相关论文
共 15 条
[1]  
Barbashin E.A., 1970, Introduction to the Theory of Stability
[2]   Global stability for a virus dynamics model with nonlinear incidence of infection and removal [J].
Georgescu, Paul ;
Hsieh, Ying-Hen .
SIAM JOURNAL ON APPLIED MATHEMATICS, 2006, 67 (02) :337-353
[3]   Global dynamics of a staged progression model for infectious diseases [J].
Guo, Hongbin ;
Li, Michael Y. .
MATHEMATICAL BIOSCIENCES AND ENGINEERING, 2006, 3 (03) :513-525
[4]  
Korobeinikov A, 2004, MATH BIOSCI ENG, V1, P57
[5]   Non-linear incidence and stability of infectious disease models [J].
Korobeinikov, A ;
Maini, PK .
MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA, 2005, 22 (02) :113-128
[6]   Global properties of basic virus dynamics models [J].
Korobeinikov, A .
BULLETIN OF MATHEMATICAL BIOLOGY, 2004, 66 (04) :879-883
[7]  
Korobeinikov A, 2004, MATH MED BIOL, V21, P75
[8]   Lyapunov functions and global stability for SIR, SIRS, and SIS epidemiological models [J].
Korobeinikov, A ;
Wake, GC .
APPLIED MATHEMATICS LETTERS, 2002, 15 (08) :955-960
[9]  
KOROBEINIKOV A, 2008, MATH MED BI IN PRESS
[10]   Global properties of infectious disease models with nonlinear incidence [J].
Korobeinikov, Andrei .
BULLETIN OF MATHEMATICAL BIOLOGY, 2007, 69 (06) :1871-1886