Membranotropic and Antiradical Properties of 2-Nitroxysuccinate 3-Hydroxy-6-Methyl-2-Ethylpyridine

被引：0
|
作者：
D. A. Poletaeva
I. I. Faingold
Yu. V. Soldatova
A. V. Smolina
B. S. Fedorov
A. B. Eremeev
R. A. Kotelnikova
机构：
[1] Russian Academy of Sciences,Institute of Problems of Chemical Physics
[2] Moscow Regional State University,Scientific Educational Center
来源：
Bulletin of Experimental Biology and Medicine | 2019年 / 167卷
关键词：
membranotropic activity; antioxidants; free radicals; monoamine oxidase; cardiovascular disease;
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摘要：
We studied membranotropic properties of NO donor 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine and its structural analog succinate 3-hydroxy-6-methyl-2-ethylpyridine (Mexidol). It was shown that the compounds under study are incorporated into modeled membranes and form long-living complexes with pyrene in the region of fatty acid tails of phospholipids. Luminol-amplified chemiluminescence analysis showed that both compounds exhibited antiradical activity and in a concentration of 0.1 mM reduced chemiluminescence intensity by more than 70%. 2-Nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine inhibited catalytic activity of monoamine oxidase A more efficiently than its structural analogue Mexidol.
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页码：744 / 746
页数：2
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