Depressive disorder moderates the effect of the FTO gene on body mass index

被引：0
作者：
M Rivera
S Cohen-Woods
K Kapur
G Breen
M Y Ng
A W Butler
N Craddock
M Gill
A Korszun
W Maier
O Mors
M J Owen
M Preisig
S Bergmann
F Tozzi
J Rice
M Rietschel
J Rucker
A Schosser
K J Aitchison
R Uher
I W Craig
C M Lewis
A E Farmer
P McGuffin
机构：
[1] MRC SGDP Centre,Department of Medical Genetics
[2] Institute of Psychiatry,Department of Psychological Medicine and Neurology
[3] King's College London,Department of Psychiatry
[4] CIBERSAM,Department of Psychiatry
[5] University of Granada,Department of Psychological Medicine and Neurology
[6] Section of Psychiatry,Department of Adult Psychiatry
[7] Institute of Neurosciences,Genetics Division
[8] Biomedical Research Centre (CIBM),Department of Psychiatry
[9] University of Lausanne,Department of Psychiatry and Psychotherapy
[10] Cardiff University School of Medicine,Department of Medical and Molecular Genetics
[11] Trinity Centre for Health Sciences,undefined
[12] St James's Hospital,undefined
[13] Wolfson Institute of Preventive Medicine,undefined
[14] Barts and The London School of Medicine,undefined
[15] Queen Mary University of London,undefined
[16] Centre for Psychiatry,undefined
[17] University of Bonn,undefined
[18] Centre for Psychiatric Research,undefined
[19] Aarhus University Hospital,undefined
[20] MRC Centre for Neuropsychiatric Genetics and Genomics,undefined
[21] School of Medicine,undefined
[22] Cardiff University,undefined
[23] University Hospital and Univeristy of Lausanne,undefined
[24] Drugs Discovery,undefined
[25] GlaxoSmithKline Research and Development,undefined
[26] Washington University School of Medicine,undefined
[27] Central Institute of Mental Health,undefined
[28] Medical University Vienna,undefined
[29] School of Medicine,undefined
[30] King's College London,undefined
来源：
Molecular Psychiatry | 2012年 / 17卷
关键词：
depression; gene; obesity; BMI; body mass index;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
There is evidence that obesity-related disorders are increased among people with depression. Variation in the FTO (fat mass and obesity associated) gene has been shown to contribute to common forms of human obesity. This study aimed to investigate the genetic influence of polymorphisms in FTO in relation to body mass index (BMI) in two independent samples of major depressive disorder (MDD) cases and controls. We analysed 88 polymorphisms in the FTO gene in a clinically ascertained sample of 2442 MDD cases and 809 controls (Radiant Study). In all, 8 of the top 10 single-nucleotide polymorphisms (SNPs) showing the strongest associations with BMI were followed-up in a population-based cohort (PsyCoLaus Study) consisting of 1292 depression cases and 1690 controls. Linear regression analyses of the FTO variants and BMI yielded 10 SNPs significantly associated with increased BMI in the depressive group but not the control group in the Radiant sample. The same pattern was found in the PsyCoLaus sample. We found a significant interaction between genotype and affected status in relation to BMI for seven SNPs in Radiant (P<0.0057), with PsyCoLaus giving supportive evidence for five SNPs (P-values between 0.03 and 0.06), which increased in significance when the data were combined in a meta-analysis. This is the first study investigating FTO and BMI within the context of MDD, and the results indicate that having a history of depression moderates the effect of FTO on BMI. This finding suggests that FTO is involved in the mechanism underlying the association between mood disorders and obesity.
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页码：604 / 611
页数：7
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