A conserved module regulates receptor kinase signalling in immunity and development

被引:0
|
作者
Thomas A. DeFalco
Pauline Anne
Sean R. James
Andrew C. Willoughby
Florian Schwanke
Oliver Johanndrees
Yasmine Genolet
Paul Derbyshire
Qian Wang
Surbhi Rana
Anne-Marie Pullen
Frank L. H. Menke
Cyril Zipfel
Christian S. Hardtke
Zachary L. Nimchuk
机构
[1] University of Zürich,Institute of Plant and Microbial Biology and Zürich
[2] University of East Anglia,Basel Plant Science Center
[3] University of Lausanne,The Sainsbury Laboratory
[4] University of North Carolina at Chapel Hill,Department of Plant Molecular Biology
[5] University of North Carolina at Chapel Hill,Department of Biology
[6] Max Planck Institute for Plant Breeding Research,Curriculum in Genetics and Molecular Biology
来源
Nature Plants | 2022年 / 8卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Ligand recognition by cell-surface receptors underlies development and immunity in both animals and plants. Modulating receptor signalling is critical for appropriate cellular responses but the mechanisms ensuring this are poorly understood. Here, we show that signalling by plant receptors for pathogen-associated molecular patterns (PAMPs) in immunity and CLAVATA3/EMBRYO SURROUNDING REGION-RELATED peptides (CLEp) in development uses a similar regulatory module. In the absence of ligand, signalling is dampened through association with specific type-2C protein phosphatases. Upon activation, PAMP and CLEp receptors phosphorylate divergent cytosolic kinases, which, in turn, phosphorylate the phosphatases, thereby promoting receptor signalling. Our work reveals a regulatory circuit shared between immune and developmental receptor signalling, which may have broader important implications for plant receptor kinase-mediated signalling in general.
引用
收藏
页码:356 / 365
页数:9
相关论文
共 50 条
  • [31] The Receptor-Like Cytoplasmic Kinase OsRLCK102 Regulates XA21-Mediated Immunity and Plant Development in Rice
    Wang, Jing
    Wu, Guanwen
    Peng, Chunfang
    Zhou, Xiaogang
    Li, Weitao
    He, Min
    Wang, Jichun
    Yin, Junjie
    Yuan, Can
    Ma, Weiwei
    Ma, Bintian
    Wang, Yuping
    Chen, Weilan
    Qin, Peng
    Li, Shigui
    Chen, Xuewei
    PLANT MOLECULAR BIOLOGY REPORTER, 2016, 34 (03) : 628 - 637
  • [32] G-protein-coupled receptor kinase 2 regulates Gαs-mediated signalling
    Quitterer, U
    Hoffmann, M
    Brockmann, J
    Krasel, C
    Lohse, MJ
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2001, 363 (04) : R54 - R54
  • [33] A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite
    Moon, Robert W.
    Taylor, Cathy J.
    Bex, Claudia
    Schepers, Rebecca
    Goulding, David
    Janse, Chris J.
    Waters, Andrew P.
    Baker, David A.
    Billker, Oliver
    PLOS PATHOGENS, 2009, 5 (09)
  • [34] beta-adrenergic receptor kinase-1 acutely regulates PTH/PTHrP receptor signalling in human osteoblastlike cells
    Fukayama, S
    Kong, GH
    Benovic, JL
    Meurer, E
    Tashjian, AH
    CELLULAR SIGNALLING, 1997, 9 (06) : 469 - 474
  • [35] The Conserved MAP Kinase MpkB Regulates Development and Sporulation without Affecting Aflatoxin Biosynthesis in Aspergillus flavus
    Jun, Sang-Cheol
    Kim, Jong-Hwa
    Han, Kap-Hoon
    JOURNAL OF FUNGI, 2020, 6 (04) : 1 - 16
  • [36] S-locus receptor kinase signalling
    Nasrallah, June B.
    Nasrallah, Mikhail E.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2014, 42 : 313 - 319
  • [37] A malectin-like receptor kinase regulates cell death and pattern-triggered immunity in soybean
    Wang, Dongmei
    Liang, Xiangxiu
    Bao, Yazhou
    Yang, Suxin
    Zhang, Xiong
    Yu, Hui
    Zhang, Qian
    Xu, Guangyuan
    Feng, Xianzhong
    Dou, Daolong
    EMBO REPORTS, 2020, 21 (11)
  • [38] Calreticulin regulates insulin receptor expression and its downstream PI3 Kinase/Akt signalling pathway
    Jalali, Shahrzad
    Aghasi, Maliheh
    Yeganeh, Behzad
    Mesaeli, Nasrin
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2008, 1783 (12): : 2344 - 2351
  • [39] Kinase signalling in excitatory neurons regulates sleep quantity and depth
    Kim, Staci J.
    Hotta-Hirashima, Noriko
    Asano, Fuyuki
    Kitazono, Tomohiro
    Iwasaki, Kanako
    Nakata, Shinya
    Komiya, Haruna
    Asama, Nodoka
    Matsuoka, Taeko
    Fujiyama, Tomoyuki
    Ikkyu, Aya
    Kakizaki, Miyo
    Kanno, Satomi
    Choi, Jinhwan
    Kumar, Deependra
    Tsukamoto, Takumi
    Elhosainy, Asmaa
    Mizuno, Seiya
    Miyazaki, Shinichi
    Tsuneoka, Yousuke
    Sugiyama, Fumihiro
    Takahashi, Satoru
    Hayashi, Yu
    Muratani, Masafumi
    Liu, Qinghua
    Miyoshi, Chika
    Yanagisawa, Masashi
    Funato, Hiromasa
    NATURE, 2022, 612 (7940) : 512 - +
  • [40] Kinase signalling in excitatory neurons regulates sleep quantity and depth
    Staci J. Kim
    Noriko Hotta-Hirashima
    Fuyuki Asano
    Tomohiro Kitazono
    Kanako Iwasaki
    Shinya Nakata
    Haruna Komiya
    Nodoka Asama
    Taeko Matsuoka
    Tomoyuki Fujiyama
    Aya Ikkyu
    Miyo Kakizaki
    Satomi Kanno
    Jinhwan Choi
    Deependra Kumar
    Takumi Tsukamoto
    Asmaa Elhosainy
    Seiya Mizuno
    Shinichi Miyazaki
    Yousuke Tsuneoka
    Fumihiro Sugiyama
    Satoru Takahashi
    Yu Hayashi
    Masafumi Muratani
    Qinghua Liu
    Chika Miyoshi
    Masashi Yanagisawa
    Hiromasa Funato
    Nature, 2022, 612 : 512 - 518