The role of microRNAs in human embryo implantation: a review

被引：0
作者：
Anthea B. M. Paul
Seifeldin T. Sadek
Arnold M. Mahesan
机构：
[1] University of Ottawa,Department of Pathology and Laboratory Medicine
[2] Eastern Virginia Medical School,The Jones Institute for Reproductive Medicine
来源：
Journal of Assisted Reproduction and Genetics | 2019年 / 36卷
关键词：
MicroRNA; Human embryo; Endometrium; Implantation; Pregnancy; Recurrent implantation failure;
D O I：
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中图分类号：
学科分类号：
摘要：
MicroRNAs (miRNAs) are emerging as important in human embryo implantation, and we present here a review of the literature from a clinical perspective. Implantation involves complex interactions between the blastocyst and endometrium. miRNAs have been shown to be differentially expressed in implanted compared with non-implanted blastocysts and euploid compared with aneuploid blastocysts. Further, miRNAs are differentially expressed in proliferative compared with decidualized endometrium, and in receptive compared with pre-receptive endometrium. miRNAs are also differentially expressed in endometrium of women who failed implantation, and in endometrium of women with recurrent implantation failure. Due to the complexity of miRNA signaling, studies have suffered from inconsistency in reproducibility of results. However, miRNAs show potential as biomarkers in the pursuit of more reliable prediction of embryo implantation.
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页码：179 / 187
页数：8
相关论文
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