UGT2B17 gene deletion associated with an increase in bone mineral density similar to the effect of hormone replacement in postmenopausal women

被引:0
作者
S. Giroux
J. Bussières
A. Bureau
F. Rousseau
机构
[1] Centre de Recherche de l’Hôpital St-François d’Assise du Centre hospitalier universitaire de Québec,Faculté de Médecine
[2] Université Laval,undefined
[3] Centre de recherche Université Laval Robert-Giffard,undefined
[4] Centre for the Development,undefined
[5] Evaluation and Rational Implementation of New Diagnostic Tools in Medicine (CEDERINDT)/The CanGèneTest Research Consortium on Genetic Laboratory Services,undefined
来源
Osteoporosis International | 2012年 / 23卷
关键词
Bone mineral density; Hormone replacement; Menopause; deletion;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1163 / 1170
页数:7
相关论文
共 188 条
  • [1] Turgeon D(2001)Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members Endocrinology 142 778-787
  • [2] Carrier JS(2001)Sex steroids and bone Physiol Rev 81 419-447
  • [3] Levesque E(2006)Common deletion polymorphisms in the human genome Nat Genet 38 86-92
  • [4] Hum DW(2008)Adaptive evolution of UGT2B17 copy-number variation Am J Hum Genet 83 337-346
  • [5] Belanger A(2008)Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation J Clin Endocrinol Metab 93 2500-2506
  • [6] Compston JE(2006)Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism J Clin Endocrinol Metab 91 687-693
  • [7] McCarroll SA(2007)The UGT2B17 gene deletion polymorphism and risk of prostate cancer. A case–control study in Caucasians Cancer Detect Prev 31 310-315
  • [8] Hadnott TN(2008)Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate Pharmacogenomics J 8 147-151
  • [9] Perry GH(2008)The UGT2B17 gene deletion is not associated with prostate cancer risk Prostate 68 571-575
  • [10] Xue Y(2006)Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men Cancer Epidemiol Biomark Prev 15 1473-1478