Ionic Liquid-Based Transcutaneous Peptide Antitumor Vaccine: Therapeutic Effect in a Mouse Tumor Model

被引:0
作者
Taro Shimizu
Takaaki Matsuzaki
Shoichiro Fukuda
Chihiro Yoshioka
Yuna Shimazaki
Shunsuke Takese
Katsuhiro Yamanaka
Takashi Nakae
Masaki Ishibashi
Hidetoshi Hamamoto
Hidenori Ando
Yu Ishima
Tatsuhiro Ishida
机构
[1] Tokushima University,Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences
[2] MEDRx Co.,undefined
[3] Ltd,undefined
来源
The AAPS Journal | / 25卷
关键词
cancer vaccine; ionic liquid; resiquimod (R848); transcutaneous delivery; WT1 peptide;
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[1]  
Steinman RM(1991)The dendritic cell system and its role in immunogenicity Annu Rev Immunol 9 271-296
[2]  
Finkelman FD(1996)Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion J Immunol 157 1406-1414
[3]  
Lees A(2011)Transcutaneous and intradermal vaccination Hum Vaccin 7 811-827
[4]  
Birnbaum R(2004)Immune surveillance in the skin: mechanisms and clinical consequences Nat Rev Immunol 4 211-222
[5]  
Gause WC(2008)Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells Immunity 29 497-510
[6]  
Morris SC(2017)Dermal and transdermal delivery of pharmaceutically relevant macromolecules Eur J Pharm Biopharm 119 235-242
[7]  
Combadiere B(2000)The 500 Dalton rule for the skin penetration of chemical compounds and drugs Exp Dermatol 9 165-169
[8]  
Liard C(2016)Dual ionic and organic nature of ionic liquids Sci Rep 6 19644-331
[9]  
Kupper TS(2008)Room temperature ionic liquids and their mixtures: potential pharmaceutical solvents Eur J Pharm Sci 33 326-559
[10]  
Fuhlbrigge RC(2013)Evaluation of solubility and partition properties of ampicillin-based ionic liquids Int J Pharm 456 553-1690