Notch signalling in cancer progression and bone metastasis

被引：0
作者：
N Sethi
Y Kang
机构：
[1] Princeton University,Department of Molecular Biology
[2] Robert Wood Johnson Medical School,undefined
[3] Genomic Instability and Tumor Progression Program,undefined
[4] Cancer Institute of New Jersey,undefined
来源：
British Journal of Cancer | 2011年 / 105卷
关键词：
Notch signalling; bone metastasis; Jagged1; tumour progression;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Classically known for its indispensible role in embryonic development, the Notch signalling pathway is gaining recognition for its regulation of adult tissue homoeostasis and aberrant activation in disease pathogenesis. The pathway has been implicated in cancer initiation and development, as well as early stages of cancer progression by regulating conserved cellular programs such as the epithelial-to-mesenchymal transition. We recently extended the role of Notch signalling to late stages of tumour progression by elucidating a stroma-dependent mechanism for the pathway in osteolytic bone metastasis. Of clinical significance, disrupting the Notch pathway and associated molecular mediators of Notch-dependent bone metastasis may provide novel therapeutic strategies to combat aggressive bone metastatic disease.
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页码：1805 / 1810
页数：5
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