Role of In Silico Tools in Gene Discovery

被引：0
作者：
Bing Yu
机构：
[1] University of Sydney,Department of Molecular & Clinical Genetics, Royal Prince Alfred Hospital and Central Clinical School
来源：
Molecular Biotechnology | 2009年 / 41卷
关键词：
Gene discovery; Complex disease; Data mining; Prediction; Data hosting; prioritization; Haplotype inference; Simulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Common complex diseases remain a major health challenge and involve the interaction of multiple genes and environmental factors. Discovering the relevant genes is difficult although it is known that disease risk can originate from the variation of an individual’s genome. Application of in silico tools can significantly improve the detection of genes and variation. Data mining and automated tracking of new knowledge facilitate locus mapping. At the gene search stage, in silico prioritization of candidate genes plays an indispensable role in dealing with linked or associated loci. In silico analysis can also differentiate subtle consequences of coding DNA variants and remains the major tool to predict potential effects of non-coding DNA variants on gene transcription and/or pre-mRNA splicing.
引用
收藏
页码：296 / 306
页数：10
相关论文
共 178 条
[1]  
Xiang J(2007)Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 661-678
[2]  
Li XY(2008)Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese Journal of Clinical Endocrinology and Metabolism 93 4107-4112
[3]  
Xu M(2006)Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nature Genetics 38 320-323
[4]  
Hong J(2006)A common genetic variant is associated with adult and childhood obesity Science 312 279-283
[5]  
Huang Y(2006)Genetic susceptibility to coronary artery disease: From promise to progress Nature Reviews. Genetics 7 163-173
[6]  
Tan JR(2008)Genome-wide association studies for complex traits: Consensus, uncertainty and challenges Nature Reviews. Genetics 9 356-369
[7]  
Grant SF(2001)Significance levels in genome scans Advances in Genetics 42 475-486
[8]  
Thorleifsson G(1958)Study of two abnormal hemoglobins with evidence for a new genetic locus for hemoglobin formation Bulletin of the Johns Hopkins Hospital 102 38-45
[9]  
Reynisdottir I(1977)Localization of the human alphaglobin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay Cell 12 205-218
[10]  
Benediktsson R(1989)Identification of the cystic fibrosis gene: Chromosome walking and jumping Science 245 1059-1065
12345678910