Modifications of the closure principle for analyzing toxicological studies

被引：0

作者：

Hothorn L.A. ^{[1
]}

机构：

[1] University of Hannover, D-30419 Hannover

来源：

Drug information journal : DIJ / Drug Information Association | 1997年 / 31卷 / 2期

关键词：

Closure principle; MED; Toxicological studies; Trend test;

D O I：

10.1177/009286159703100211

中图分类号：

学科分类号：

摘要：

A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held on March, 25-27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development. This paper proposes a simple closure test for dose-response relationships under real data conditions. This approach takes into account deviation from variance homogeneity and monotonicity assumptions. Moreover, this approach can be easily adapted for “any” kind of two-sample tests, for example, nonparametric, dichotomous, censored, and so forth. Power was compared by a simulation study for selected conditions. © 1997, Drug Information Association. All rights reserved.

引用

页码：403 / 412

页数：9

共 33 条

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