Effect of Treadmill Exercise on Blood Glucose, Serum Corticosterone Levels and Glucocorticoid Receptor Immunoreactivity in the Hippocampus in Chronic Diabetic Rats

被引：0
作者：
In Koo Hwang
Sun Shin Yi
Ki-Yeon Yoo
Ok Kyu Park
Bingchun Yan
Wook Song
Moo-Ho Won
Yeo Sung Yoon
Je Kyung Seong
机构：
[1] Seoul National University,Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute For Veterinary Science
[2] Marquette University,Department of Biomedical Sciences, College of Health Sciences
[3] Hallym University,Institute of Natural Medicine
[4] Hallym University,Department of Anatomy and Neurobiology, College of Medicine
[5] Seoul National University,Institute of Sports Science
[6] Kangwon National University,Department of Neurobiology, School of Medicine
来源：
Neurochemical Research | 2011年 / 36卷
关键词：
Type 2 diabetes; Treadmill exercise; Corticosteroid; Glucocorticoid receptor; Hippocampus; Immunohistochemistry;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Abnormal excess of glucocorticoid is one of feature characteristics in type 2 diabetes. In the present study, we investigated the effect of treadmill exercise at chronic diabetic stages on glucocorticoid receptor (GR) immunoreactivity in the hippocampal CA1 region and dentate gyrus, which are very vulnerable to diabetes. For this study, we used Zucker diabetic fatty (ZDF) rats and Zucker lean control (ZLC) rats. Twenty-three-week-old ZLC and ZDF rats were put on the treadmill with or without running for 7 weeks and sacrificed at 30 weeks of age. Treadmill exercise significantly decreased diabetes-induced blood glucose and serum corticosteroid levels although they did not drop to control levels. In sedentary ZLC rats, GR immunoreactivity was detected in pyramidal cells of the CA1 region as well as in granule cells of the dentate gyrus. In the sedentary ZDF rats, GR immunoreactivity was significantly increased in these regions. However, treadmill exercise significantly decreased GR immunoreactivity in these regions. These results indicate that treadmill exercise in chronic diabetic rats significantly decreased GR immunoreactivity in the hippocampal CA1 region and dentate gyrus, although blood glucose and serum corticosteroid levels did not fully recover to normal state.
引用
收藏
页码：281 / 287
页数：6
相关论文
共 139 条
[1]  
Serrano Rios M(1998)Relationship between obesity and the increased risk of major complications in non-insulin-dependent diabetes mellitus Eur J Clin Invest 28 14-17
[2]  
Goldberg RB(2000)Hyperlipidemia and cardiovascular risk factors in patients with type 2 diabetes Am J Manag Care 6 S682-S691
[3]  
Carr MC(2004)Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk J Clin Endocrinol Metab 89 2601-2607
[4]  
Brunzell JD(2002)Adiposity and the development of diabetes in mouse genetic models Ann N Y Acad Sci 967 80-87
[5]  
Kozak LP(2004)Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes Diabetes 53 S4-S11
[6]  
Rossmeisl M(2005)Development and application of rodent models for type 2 diabetes Diabetes Obes Metab 7 307-317
[7]  
Leiter EH(1979)Adrenal gland involvement in mice with hereditary obesity and diabetes mellitus. Morphological studies Diabetologia 16 391-398
[8]  
Reifsnyder PC(1997)Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes Regul Pept 72 105-112
[9]  
Chen D(2002)Adrenal and gonadal function in obesity J Endocrinol Invest 25 893-898
[10]  
Wang MW(2007)Adrenocortical insufficiency in Otsuka Long-Evans Tokushima fatty rats, a type 2 diabetes mellitus model Metabolism 56 1326-1333
12345678910