Fluid strategies and outcomes in patients with acute respiratory distress syndrome, systemic inflammatory response syndrome and sepsis: A protocol for a systematic review and meta-analysis

被引：10

作者：

Silversides J.A. ^{[1
,2
]}

Ferguson A.J. ^{[3
]}

McAuley D.F. ^{[1
,2
]}

Blackwood B. ^{[1
]}

Marshall J.C. ^{[4
,5
]}

Fan E. ^{[4
,6
]}

机构：

[1] Queen's University Belfast, Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, 97 Lisburn Road, Belfast

[2] Belfast Health and Social Care Trust, Critical Care Services, Belfast

[3] Craigavon Area Hospital, Department of Anaesthetics and Intensive Care, Southern Health and Social Care Trust, 68 Lurgan Road, Portadown

[4] University of Toronto, Toronto General Hospital, Interdepartmental Division of Critical Care, 585 University Avenue, PMB 11-123, Toronto, M5G 2N2, ON

[5] St. Michael's Hospital, Toronto, Critical Care Medicine, 30 Bond Street, Bond 4-014, Toronto, M5B 1W8, ON

[6] University Health Network and Mount Sinai Hospitals, Critical Care Medicine, Toronto

来源：

Systematic Reviews | / 4卷 / 1期

关键词：

Adult; Critical illness; Deresuscitation; Diuretics; Fluid therapy; Respiratory distress syndrome; Sepsis; Sepsis syndrome; Systemic inflammatory response syndrome; Ultrafiltration;

D O I：

10.1186/s13643-015-0150-z

中图分类号：

学科分类号：

摘要：

Background: Fluid administration to critically ill patients remains the subject of considerable controversy. While intravenous fluid given for resuscitation may be life-saving, a positive fluid balance over time is associated with worse outcomes in critical illness. The aim of this systematic review is to summarise the existing evidence regarding the relationship between fluid administration or balance and clinically important patient outcomes in critical illness. Methods: We will search Medline, EMBASE, the Cochrane Central Register of Controlled Trials from 1980 to the present and key conference proceedings from 2009 to the present. We will include studies of critically ill adults and children with acute respiratory distress syndrome (ARDS), sepsis and systemic inflammatory response syndrome (SIRS). We will include randomised controlled trials comparing two or more fluid regimens of different volumes of fluid and observational studies reporting the relationship between volume of fluid administered or fluid balance and outcomes including mortality, lengths of intensive care unit and hospital stay and organ dysfunction. Two independent reviewers will assess articles for eligibility, data extraction and quality appraisal. We will conduct a narrative and/or meta-analysis as appropriate. Discussion: While fluid management has been extensively studied and discussed in the critical care literature, no systematic review has attempted to summarise the evidence for post-resuscitation fluid strategies in critical illness. Results of the proposed systematic review will inform practice and the design of future clinical trials. Systematic review registration: PROSPERO CRD42013005608. ( http://www.crd.york.ac.uk/PROSPERO/ ) © 2015 Silversides et al.

引用

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