The emerging treatment landscape of targeted therapy in non-small-cell lung cancer

被引：0
作者：
Min Yuan
Li-Li Huang
Jian-Hua Chen
Jie Wu
Qing Xu
机构：
[1] Tongji University School of Medicine,Department of Oncology, Dermatology Hospital
[2] Tongji University School of Medicine,Department of Oncology, Shanghai Tenth People’s Hospital
[3] University of Oklahoma Health Sciences Center,Peggy and Charles Stephenson Cancer Center
[4] University of Oklahoma Health Sciences Center,Department of Pathology
来源：
Signal Transduction and Targeted Therapy | / 4卷
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摘要：
Lung cancer is one of the most common cancer in the world. In 2018, there were over 2 million new cases of lung cancer and over 1.7 million deaths were attributed to lung cancer. Targeted therapy has emerged as an important mean of the disease management for patients with non-small-cell lung cancer (NSCLC). Herein, we review and analyze recent literature, discuss the targeting pathways and ongoing clinical trials in lung cancer. Chemotherapy is no longer the best available treatment for all patients. Therapeutic decisions should be guided by an understanding of the molecular features of patient’s tumor tissues. The future gains will likely emerge from finding optimal ways of combining targeted therapy, immunotherapy, and chemotherapy.
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