The Influence of Ethanol on the Functional Status of GABAA Receptors

被引：0
作者：
A. I. Golovko
S. I. Golovko
L. V. Leontieva
S. Yu. Zefirov
机构：
[1] Regional Therapeutic and Diagnostic Medical Center “Bekhterev”,
[2] West Virginia University,undefined
来源：
Biochemistry (Moscow) | 2002年 / 67卷
关键词：
GABA receptors; ethanol; subunits; expression;
D O I：
暂无
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学科分类号：
摘要：
Gamma aminobutyric acid (GABA) is one of the main inhibitory neurotransmitters in the mammalian brain. Its effects are realized via GABAA, GABAB, and GABAC receptors. GABAA is the most abundant type of GABA receptors. It consists of six classes of subunits, α, β, γ, δ, ε, and χ. Acute and chronic exposures to ethanol are accompanied by changes in structure and function of GABAA receptors. These changes may be a basis for altered behavior seen in alcoholism.
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页码：719 / 729
页数：10
相关论文
共 253 条
  • [1] Hodge C. W.(2001)undefined Psychopharmacology (Berlin) 154 13-22
  • [2] Cox A. A.(1999)undefined Brain Res. Rev. 29 196-217
  • [3] Bratt A. M.(1997)undefined Alcoholism Clin. Exp. Res. 21 745-748
  • [4] Camarini R.(1983)undefined J. Pharmacol. Exp. Ther. 227 663-670
  • [5] Iller K.(1996)undefined Alcoholism Clin. Exp. Res. 20 1669-1674
  • [6] Kelley S. P.(1997)undefined Mol. Pharmacol. 51 588-596
  • [7] Mehmert K. K.(1997)undefined Alcoholism Clin. Exp. Res. 21 430-433
  • [8] Nannini M. A.(1997)undefined Alcoholism Clin. Exp. Res. 21 73A-188
  • [9] Olive M. F.(1997)undefined Alcoholism Clin. Exp. Res. 21 74A-44A
  • [10] Mehta A. K.(1998)undefined J. Pharmacol. Exp. Ther. 284 180-2638
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