Monocytes with Oncogenic Mutation JAK2 V617F as a Tool for Studies of the Pathogenic Mechanisms of Myelofibrosis

被引：0
作者：
A. A. Silyutina
I. I. Gin
S. S. Prikhod’ko
S. V. Zhuk
P. A. Butylin
A. Yu. Zaritskii
机构：
[1] V. A. Almazov National Medical Research Centre,Research Laboratory of Oncohematology, Institute of Hematology
来源：
Bulletin of Experimental Biology and Medicine | 2018年 / 164卷
关键词：
primary myelofibrosis; myeloproliferative neoplasms; JAK2 V617F; macrophages;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We analyzed previously generated stable monocyte-derived cell line carrying mutation JAK2 V617F. Evaluation of the expression of pro- and antifibrotic factors revealed changes in the production of MMPs and their inhibitors, growth factors, galectin-3, and pentraxin 3 in cells carrying mutation JAK2 in comparison with control non-modified cells.
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页码：569 / 575
页数：6
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