5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription

被引：0

作者：

Matthew W Kellinger

Chun-Xiao Song

Jenny Chong

Xing-Yu Lu

Chuan He

Dong Wang

机构：

[1] Skaggs School of Pharmacy and Pharmaceutical Sciences,Department of Chemistry and Institute for Biophysical Dynamics

[2] University of California,undefined

[3] San Diego,undefined

[4] La Jolla,undefined

[5] California,undefined

[6] USA.,undefined

[7] University of Chicago,undefined

来源：

Nature Structural & Molecular Biology | 2012年 / 19卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A systematic in vitro analysis of five different forms of cytosine in mammalian and yeast RNA polymerase II (Pol II) transcription demonstrates that Pol II can read and distinguish subtle differences in modified cytosines and process them differently, suggesting a putative functional interplay between cytosine modification status and transcription.

引用

页码：831 / 833

页数：2

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