Sirtuins, aging, and cardiovascular risks

被引：0
作者：
Gaia Favero
Lorenzo Franceschetti
Luigi Fabrizio Rodella
Rita Rezzani
机构：
[1] University of Brescia,Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences
[2] Interdipartimental University Center of Research “Adaption and Regeneration of Tissues and Organs (ARTO)”,undefined
来源：
AGE | 2015年 / 37卷
关键词：
Aging; Cardiovascular risk; Heart; Sirtuins; Oxidative stress; Vessel;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The sirtuins comprise a highly conserved family proteins present in virtually all species from bacteria to mammals. Sirtuins are members of the highly conserved class III histone deacetylases, and seven sirtuin genes (sirtuins 1–7) have been identified and characterized in mammals. Sirtuin activity is linked to metabolic control, apoptosis, cell survival, development, inflammation, and healthy aging. In this review, we summarize and discuss the potential mutual relations between each sirtuin and cardiovascular health and the impact of sirtuins on oxidative stress and so age-related cardiovascular disorders, underlining the possibility that sirtuins will be novel targets to contrast cardiovascular risks induced by aging.
引用
收藏
相关论文
共 1247 条
[1]  
Ahuja N(2007)Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase J Biol Chem 282 33583-33592
[2]  
Schwer B(2007)Sirt1 regulates aging and resistance to oxidative stress in the heart Circ Res 100 1512-1521
[3]  
Carobbio S(2004)Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes Circ Res 95 971-980
[4]  
Waltregny D(2012)dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner Cell Rep 2 1485-1491
[5]  
North BJ(2013)Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles Mol Cell Biol 33 252-264
[6]  
Castronovo V(2012)SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation Nature 487 114-118
[7]  
Maechler P(2012)Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov 11 443-461
[8]  
Verdin E(2012)SIRT1 modulates MAPK pathways in ischemic-reperfused cardiomyocytes Cell Mol Life Sci 69 2245-2260
[9]  
Alcendor RR(2009)Resveratrol is not a direct activator of SIRT1 enzyme activity Chem Biol Drug Des 74 619-624
[10]  
Gao S(2007)Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13 Genomics 89 143-150
12345678910