Molecular factors related to metastasis of esophageal squamous cell carcinoma

被引：3
作者：
Shimada Y. [1 ]
Sato F. [2 ]
机构：
[1] First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501
[2] Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
来源：
Esophagus | 2007年 / 4卷 / 1期
关键词：
Esophageal cancer; Hematogenous metastasis; Isolated tumor cell; Lymph node metastasis; Metastatic potential;
D O I：
10.1007/s10388-006-0101-9
中图分类号：
学科分类号：
摘要：
The aggressive behavior of esophageal cancer leads to a low survival rate for patients with this disease. Isolated esophageal cancer cells seem to have the potential for regrowth and metastasis. To control the metastasis of esophageal carcinoma, detailed analysis of various molecular and biological factors should be done in each patient. Recent progress in molecular biology has revealed that oncogenes, suppressor genes, growth factors and their receptors, adhesion molecules, angiogenic factors, cytokines, and apoptotic factors are related to the growth and metastasis of esophageal carcinoma. Among them, several genes have been identified as having a crucial role in establishing the metastasis of esophageal carcinoma, and multiple genetic alterations may underlie the metastatic process. Microarray analysis has also revealed several genetic networks that are involved in the metastasis of esophageal cancer. These recent findings regarding the metastasis of esophageal cancer are summarized in the present review. © 2007 Japan Esophageal Society and Springer-Verlag.
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页码：7 / 18
页数：11
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