Regio- and diastereoselective synthesis of N-substituted 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones

被引：0
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作者：
Evgeny А. Kvetkin
Dmitry V. Osipov
Pavel E. Krasnikov
Vitaly А. Osyanin
Yuri N. Klimochkin
机构：
[1] Samara State Technical University,
来源：
Chemistry of Heterocyclic Compounds | 2020年 / 56卷
关键词：
2-acyl-3-aryl-3,5-dihydrofuro[3,2-; ]pyridin-4(2; )-ones; pyridinium ylides; MIRC reaction; multicomponent reactions;
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摘要：
The three-component condensation of pyridinium acylmethylides generated in situ with aromatic aldehydes and 4-hydroxy-6-methylpyridones gave a series of 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones. The reaction proceeds diastereoselectively with the formation of trans-isomers and represents a cascade process involving the Knoevenagel condensation, the carbo-Michael reaction, and intramolecular nucleophilic substitution.
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页码：1423 / 1428
页数：5
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