Implications of Necroptosis for Cardiovascular Diseases

被引：0
作者：
Zhao-hui Ruan
Zi-xuan Xu
Xue-yun Zhou
Xian Zhang
Lei Shang
机构：
[1] Affiliated Eye Hospital of Nanchang University,Jiangxi Research Institute of Ophthalmology and Visual Sciences
来源：
Current Medical Science | 2019年 / 39卷
关键词：
cell death; death-associated molecular patterns; necroptosis; cardiovascular disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Necroptosis is a non-apoptotic programmed cell death pathway, which causes necrosis-like morphologic changes and triggers inflammation in the surrounding tissues. Accumulating evidence has demonstrated that necroptosis is involved in a number of pathological processes that lead to cardiovascular diseases. However, the exact molecular pathways linking them remain unknown. Herein, this review summarizes the necroptosis-related pathways involved in the development of various cardiovascular diseases, including atherosclerosis, cardiac ischemia-reperfusion injury, cardiac hypertrophy, dilated cardiomyopathy and myocardial infarction, and may shed light on the diagnosis and treatment of these diseases.
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页码：513 / 522
页数：9
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