New perspectives on glutamate receptor antagonists as antidepressants

被引：0
|
作者：
ChiHye Chung
机构：
[1] Konkuk University,Department of Biological Sciences
来源：
Archives of Pharmacal Research | 2012年 / 35卷
关键词：
NMDA; Ketamine; Major Depressive Disorder; Glutamate Receptor Antagonist; NMDAR Antagonist;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Classical antidepressants elevate the monoamine levels in the brain by preventing re-uptake of monoamines after release. Treatment of depression with monoamine re-uptake inhibitors is associated with low clinical efficacy and remission rate due to the delayed onset of therapeutic responses. Therefore, the development of alternative antidepressants is essential for successful treatment of this disease. Recently, glutamate receptor antagonists including ketamine and 2-methyl-6-(phenylethynyl)-pyridine (MPEP) have received wide attention as fast-acting therapeutic alternatives for treatment of depression.
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页码：573 / 577
页数：4
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