PS8 - 47. Treatment with sulodexide, an endothelial glycocalyx-mimetic, improves glucose tolerance in high-fat diet-fed mice

被引：0

作者：

Bart J.M. Eskens

Hans Vink

Jurgen W.G.E. Van Teeffelen

机构：

[1] Maastricht University,Department of Physiology, Cardiovascular Research Institute Maastricht

来源：

Nederlands Tijdschrift voor Diabetologie | 2011年 / 9卷 / 3期

关键词：

Glucose; Drinking Water; Diabetes Patient; Glucose Tolerance; Blood Glucose Level;

D O I：

10.1007/s12467-011-0072-x

中图分类号：

学科分类号：

摘要：

We previously showed that degradation of the endothelial glycocalyx contributes to peripheral insulin resistance. In type II diabetes patients, endothelial glycocalyx dimensions in the sublingual microcirculation were recently found to be decreased compared to healthy subjects, but to be improved by sulodexide, a mixture of glycosaminoglycan components present in the endothelial glycocalyx (Broekhuizen et al. 2010). In the current study we tested if sulodexide treatment could ameliorate the deterioration in whole-body glucose tolerance induced by a high-fat diet (HFD) in mice.

引用

页码：123 / 123