Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)- 5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives

被引：0
|
作者：
V. L. Gein
N. N. Kasimova
S. V. Chashchina
A. V. Starkova
B. Ya. Syropyatov
机构：
[1] Ministry of Health of the RF,Perm State Pharmaceutical Academy
来源：
Pharmaceutical Chemistry Journal | 2019年 / 53卷
关键词：
4-acyl-1-(2-aminopropyl)-5-aryl-3-hydroxy-3-pyrrolin-2-ones; pyrrolo[3; 4-; ]pyrazole; synthesis; anti-inflammatory activity; analgesic activity; hemostatic effect;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of 1-(2-aminopropyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by three-component reactions of 4-substituted 2,4-dioxobutanoic acid methyl esters with mixtures of an aromatic aldehyde and 1,2-diaminopropane. Products of their reactions with hydrazine, p-phenetidine, and acetic anhydride were obtained. The analgesic, anti-inflammatory, and antimicrobial activities and hemostatic effect of several compounds were studied.
引用
收藏
页码：701 / 705
页数：4
相关论文
共 50 条
  • [1] Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)-5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives
    Gein, V. L.
    Kasimova, N. N.
    Chashchina, S., V
    Starkova, A., V
    Syropyatov, B. Ya
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2019, 53 (08) : 701 - 705
  • [2] Anti-inflammatory and analgesic activity of 5-aryl-4-acyl-1-heteryl-3- hydroxy-3-pyrrolin-2-ones
    Gein V.L.
    Yushkov V.V.
    Splina T.A.
    Gein L.F.
    Yatsenko K.V.
    Shevtsova S.G.
    Pharmaceutical Chemistry Journal, 2008, 42 (5) : 255 - 257
  • [3] Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-Aroyl-3-Hydroxy-1-Carboxymethyl-3-Pyrrolin-2-Ones
    Pastukhova, E. V.
    Chashchina, S. V.
    Ivanova, A. S.
    Petrova, E. E.
    Gein, V. L.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2022, 56 (09) : 1188 - 1191
  • [4] Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-Aroyl-3-Hydroxy-1-Carboxymethyl-3-Pyrrolin-2-Ones
    E. V. Pastukhova
    S. V. Chashchina
    A. S. Ivanova
    E. E. Petrova
    V. L. Gein
    Pharmaceutical Chemistry Journal, 2022, 56 : 1188 - 1191
  • [5] Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1-Carboxymethyl-3-PyrroliN-2-Ones
    Pastukhova, E. V.
    Chashchina, S. V.
    Buldakova, E. A.
    Gein, V. L.
    Mokrushin, I. G.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2023, 57 (02) : 204 - 208
  • [6] Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1-Carboxymethyl-3-PyrroliN-2-Ones
    E. V. Pastukhova
    S. V. Chashchina
    E. A. Buldakova
    V. L. Gein
    I. G. Mokrushin
    Pharmaceutical Chemistry Journal, 2023, 57 (2) : 204 - 208
  • [7] Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1-Carboxymethyl-3-Pyrrolin-2-Ones
    Pastukhova, E. V.
    Chashchina, S. V.
    Buldakova, E. A.
    Gein, V. L.
    Mokrushin, I. G.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2023,
  • [8] Anti-Inflammatory Activity of 5-Aryl-4-Hetaroyl-3-Hydroxy-1-Hydroxyalkyl-3-Pyrrolin-2-Ones
    Gein, O. N.
    Mazunina, I. M.
    Gein, V. S.
    Rubtsova, D. D.
    Gein, V. L.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2024, 58 (08) : 1263 - 1266
  • [9] Synthesis and Analgesic Activity of 5-Aryl-4-Heteroyl-3-Hydroxy-1-(2-Thiazolyl)-3-Pyrrolin-2-Ones and their Derivatives
    V. L. Gein
    M. A. Mar’yasov
    T. A. Silina
    R. R. Makhmudov
    Pharmaceutical Chemistry Journal, 2014, 47 : 539 - 543
  • [10] Synthesis and Analgesic Activity of 5-Aryl-4-Heteroyl-3-Hydroxy-1-(2-Thiazolyl)-3-Pyrrolin-2-Ones and their Derivatives
    Gein, V. L.
    Mar'yasov, M. A.
    Silina, T. A.
    Makhmudov, R. R.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2014, 47 (10) : 539 - 543
12345