The relationship between diabetes and pancreatic cancer

被引：191
作者：
Feng Wang
Margery Herrington
Jörgen Larsson
Johan Permert
机构：
[1] Surgery Department, Karolinska Institute, Huddinge University Hospital
[2] Department of Biology, Adams Stage College, Alamosa
来源：
Molecular Cancer | / 2卷 / 1期
关键词：
Pancreatic Cancer; Pancreatic Cancer Cell; Pancreatic Cancer Cell Line; Pancreatic Cancer Patient; Human Pancreatic Cancer Cell;
D O I：
10.1186/1476-4598-2-4
中图分类号：
学科分类号：
摘要：
About 80% of pancreatic cancer patients have glucose intolerance or frank diabetes. This observation has led to the following two hypotheses: i. pancreatic cancer causes the associated diabetes and ii. the conditions associated with diabetes promote the development of pancreatic cancer. Evidence supporting both hypotheses has been accumulated in previous studies. This article reviews these studies, especially those that have been conducted recently. -cr 2003 Wang et al; licensee BioMed Central Ltd.
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页数：5
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共 61 条
[21]  
Ishikawa O., Nakamori S., Ohigashi H., Immaoka S., Increased secretion of proinsulin in patients with pancreatic cancer, Int. J. Pancreatol., 16, pp. 86-89, (1994)
[22]  
Permert J., Larsson J., Fruin A.B., Tatemoto K., Herrington M.K., von Schenck H., Adrian T.E., Islet hormone secretion in pancreatic cancer patients with diabetes, Pancreas, 15, pp. 60-68, (1997)
[23]  
Permert J., Herrington M., Kazakoff K., Pour P.M., Adrian T.E., Early changes in islet hormone secretion in the hamster pancreatic cancer model, Teratog. Carcinog. Mutagen., 21, pp. 59-67, (2001)
[24]  
Pour P.M., Permert J., Mogaki M., Fujii H., Kazakoff K., Endocrine aspects of exocrine cancer of the pancreas. Their patterns and suggested biologic significance, Am. J. Clin. Pathol., 100, pp. 223-230, (1993)
[25]  
Permert J., Larsson J., Westermark G.T., Herrington M.K., Christmanson L., Pour P.M., Westermark P., Adrian T.E., Islet amyloid polypeptide in patients with pancreatic cancer and diabetes, N. Engl. J. Med., 330, pp. 313-318, (1994)
[26]  
Chari S.T., Klee G.G., Miller L.J., Raimondo M., DiMagno E.P., Islet amyloid polypeptide is not a satisfactory marker for detecting pancreatic cancer, Gastroenterology, 121, pp. 640-645, (2001)
[27]  
Makimattila S., Hietaniemi K., Kiviluoto T., Timonen T., Yki-Jarvinen H., In vivo glucose-stimulated amylin secretion is increased in nondiabetic patients with pancreatic cancer, Metabolism, 5, pp. 1036-1042, (2001)
[28]  
Ding X., Flatt P.R., Permert J., Adrian T.E., Pancreatic cancer cells selectively stimulate islet beta cells to secrete amylin, Gastroenterology, 114, pp. 130-138, (1998)
[29]  
Oosterwijk C., van Hulst K.L., Visser C.J., Woutersen R.A., Lips C.J., van den Tweel J.G., Hoppener J.W., Pancreatic cancer in rats and hamsters does not induce IAPP-related hyperglycaemia, Int. J. Cancer, 72, pp. 637-641, (1997)
[30]  
Wang F., Adrian T.E., Westermark G.T., Ding X., Gasslander T., Permert J., Islet amyloid polypeptide tonally inhibits beta-, alpha-, and delta-cell secretion in isolated rat pancreatic islets, Am. J. Physiol., 276, (1999)
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