Effect of Age and Sex on Lacosamide Pharmacokinetics in Healthy Adult Subjects and Adults with Focal Epilepsy

[1] Gandhi M(2004)Sex differences in pharmacokinetics and pharmacodynamics Annu Rev Pharmacol Toxicol. 44 499-523

[2] Aweeka F(2005)Pharmacokinetic variability of new antiepileptic drugs at different ages Ther Drug Monit. 27 714-717

[3] Greenblatt RM(2013)Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age: an update Clin Pharmacokinet. 52 627-645

[4] Blaschke TF(2006)Pharmacological and clinical aspects of antiepileptic drug use in the elderly Epilepsy Res. 68 S49-S63

[5] Perucca E(2008)The elderly—a challenge for appropriate drug treatment Eur J Clin Pharmacol. 64 225-226

[6] Italiano D(2005)Water balance, hydration status, and fat-free mass hydration in younger and older adults Am J Clin Nutr. 81 1342-1350

[7] Perucca E(1999)Renal handling of drugs in the healthy elderly: creatinine clearance underestimates renal function and pharmacokinetics remain virtually unchanged Eur J Clin Pharmacol. 55 205-211

[8] Perucca E(1998)Antiepileptic drug use in nursing home residents: effect of age, gender, and comedication on patterns of use Epilepsia. 39 1083-1087

[9] Berlowitz D(2008)Treatment of epilepsy in the elderly Curr Treat Options Neurol. 10 239-245

[10] Birnbaum A(1988)Pharmacokinetics of vigabatrin: implications of creatinine clearance Clin Pharmacol Ther. 44 558-565

[1] Gandhi M(2004)Sex differences in pharmacokinetics and pharmacodynamics Annu Rev Pharmacol Toxicol. 44 499-523

[2] Aweeka F(2005)Pharmacokinetic variability of new antiepileptic drugs at different ages Ther Drug Monit. 27 714-717

[3] Greenblatt RM(2013)Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age: an update Clin Pharmacokinet. 52 627-645

[4] Blaschke TF(2006)Pharmacological and clinical aspects of antiepileptic drug use in the elderly Epilepsy Res. 68 S49-S63

[5] Perucca E(2008)The elderly—a challenge for appropriate drug treatment Eur J Clin Pharmacol. 64 225-226

[6] Italiano D(2005)Water balance, hydration status, and fat-free mass hydration in younger and older adults Am J Clin Nutr. 81 1342-1350

[7] Perucca E(1999)Renal handling of drugs in the healthy elderly: creatinine clearance underestimates renal function and pharmacokinetics remain virtually unchanged Eur J Clin Pharmacol. 55 205-211

[8] Perucca E(1998)Antiepileptic drug use in nursing home residents: effect of age, gender, and comedication on patterns of use Epilepsia. 39 1083-1087

[9] Berlowitz D(2008)Treatment of epilepsy in the elderly Curr Treat Options Neurol. 10 239-245

[10] Birnbaum A(1988)Pharmacokinetics of vigabatrin: implications of creatinine clearance Clin Pharmacol Ther. 44 558-565