Dexmedetomidine inhibits Tetrodotoxin-resistant Nav1.8 sodium channel activity through Gi/o-dependent pathway in rat dorsal root ganglion neurons

被引：0
|
作者：
Xi-Yao Gu
Ben-Long Liu
Kai-Kai Zang
Liu Yang
Hua Xu
Hai-Li Pan
Zhi-Qi Zhao
Yu-Qiu Zhang
机构：
[1] Fudan University,Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science
[2] The Second Military Medical University,Department of Anesthesiology, Changhai Hospital
[3] Nanchang University,Center for Neuropsychiatric Diseases, Institute of Life Science
来源：
Molecular Brain | / 8卷
关键词：
α2-adrenoceptor; Dexmedetomidine; Dorsal root ganglion; Pain; Tetrodotoxin-resistant (TTX-R) sodium channel Na; 1.8; Whole-cell recording;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 28 条
  • [1] Dexmedetomidine inhibits Tetrodotoxin-resistant Nav1.8 sodium channel activity through Gi/o-dependent pathway in rat dorsal root ganglion neurons
    Gu, Xi-Yao
    Liu, Ben-Long
    Zang, Kai-Kai
    Yang, Liu
    Xu, Hua
    Pan, Hai-Li
    Zhao, Zhi-Qi
    Zhang, Yu-Qiu
    MOLECULAR BRAIN, 2015, 8
  • [2] Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons
    Wei Lin
    Wen-Wen Zhang
    Ning Lyu
    Hong Cao
    Wen-Dong Xu
    Yu-Qiu Zhang
    Neuroscience Bulletin, 2021, 37 : 1289 - 1302
  • [3] Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons
    Lin, Wei
    Zhang, Wen-Wen
    Lyu, Ning
    Cao, Hong
    Xu, Wen-Dong
    Zhang, Yu-Qiu
    NEUROSCIENCE BULLETIN, 2021, 37 (09) : 1289 - 1302
  • [4] Stromal Cell-Derived Factor 1 Increases Tetrodotoxin-Resistant Sodium Currents Nav1.8 and Nav1.9 in Rat Dorsal Root Ganglion Neurons via Different Mechanisms
    Qiu, Fang
    Li, Yang
    Fu, Qiang
    Fan, Yong-Yan
    Zhu, Chao
    Liu, Yan-Hong
    Mi, Wei-Dong
    NEUROCHEMICAL RESEARCH, 2016, 41 (07) : 1587 - 1603
  • [5] Stromal Cell-Derived Factor 1 Increases Tetrodotoxin-Resistant Sodium Currents Nav1.8 and Nav1.9 in Rat Dorsal Root Ganglion Neurons via Different Mechanisms
    Fang Qiu
    Yang Li
    Qiang Fu
    Yong-Yan Fan
    Chao Zhu
    Yan-Hong Liu
    Wei-Dong Mi
    Neurochemical Research, 2016, 41 : 1587 - 1603
  • [6] A comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglion neurons
    Farrag, K. J.
    Bhattacharjee, A.
    Docherty, R. J.
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2008, 455 (05): : 929 - 938
  • [7] A comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglion neurons
    K. J. Farrag
    A. Bhattacharjee
    R. J. Docherty
    Pflügers Archiv - European Journal of Physiology, 2008, 455 : 929 - 938
  • [8] The involvement of the tetrodotoxin-resistant sodium channel Nav1.8 (PN3/SNS) in a rat model of visceral pain
    Yoshimura, N
    Seki, S
    Novakovic, SD
    Tzoumaka, E
    Erickson, VL
    Erickson, KA
    Chancellor, MB
    de Groat, WC
    JOURNAL OF NEUROSCIENCE, 2001, 21 (21) : 8690 - 8696
  • [9] SINGLE-CHANNEL ANALYSIS OF TETRODOTOXIN-SENSITIVE AND TETRODOTOXIN-RESISTANT SODIUM-CHANNELS IN RAT DORSAL-ROOT GANGLION NEURONS
    ROY, ML
    REUVENY, E
    NARAHASHI, T
    BRAIN RESEARCH, 1994, 650 (02) : 341 - 346
  • [10] N-Ethylmaleimide modulation of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons
    Song, JH
    Jang, YY
    Shin, YK
    Lee, CS
    Chung, S
    BRAIN RESEARCH, 2000, 855 (02) : 267 - 273
123