The effect of food on the pharmacokinetics of oral ibrutinib in healthy participants and patients with chronic lymphocytic leukemia

被引:0
作者
Jan de Jong
Juthamas Sukbuntherng
Donna Skee
Joe Murphy
Susan O’Brien
John C. Byrd
Danelle James
Peter Hellemans
David J. Loury
Juhui Jiao
Vijay Chauhan
Erik Mannaert
机构
[1] Janssen Research & Development,
[2] LLC,undefined
[3] La Jolla,undefined
[4] Pharmacyclics,undefined
[5] Inc.,undefined
[6] Janssen Research & Development,undefined
[7] University of Texas,undefined
[8] MD Anderson Cancer Center,undefined
[9] Ohio State University,undefined
[10] Janssen Research & Development,undefined
来源
Cancer Chemotherapy and Pharmacology | 2015年 / 75卷
关键词
Chronic lymphocytic leukemia; Food effect; Ibrutinib; Pharmacokinetics; Tyrosine kinase inhibitor;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:907 / 916
页数:9
相关论文
共 234 条
[1]  
Byrd JC(2013)Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia N Engl J Med 369 32-42
[2]  
Furman RR(2013)Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma N Engl J Med 369 507-516
[3]  
Coutre SE(2013)Cancer statistics, 2013 CA Cancer J Clin 63 11-30
[4]  
Flinn IW(2006)Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma Br J Haematol 132 303-316
[5]  
Burger JA(2011)Update on therapy of chronic lymphocytic leukemia J Clin Oncol 29 544-550
[6]  
Blum KA(2014)Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia N Engl J Med 371 213-223
[7]  
Grant B(2005)Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia J Clin Oncol 23 4070-4078
[8]  
Sharman JP(2005)Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011 Blood 105 49-53
[9]  
Coleman M(2012)Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia Blood 120 4684-4691
[10]  
Wierda WG(2013)Targeting B-Cell receptor signaling for anticancer therapy: the Bruton’s tyrosine kinase inhibitor ibrutinib induces impressive responses in B-cell malignancies J Clin Oncol 31 128-130