TGFβ Signaling Pathways and Human Diseases

被引：0
作者：
Richard W. Padgett
机构：
[1] Rutgers University,Waksman Institute, The Department of Molecular Biology and Biochemistry, and The Cancer Institute of New Jersey
来源：
Cancer and Metastasis Reviews | 1999年 / 18卷
关键词：
TGFβ; Smads; cancer; development; growth factors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent progress in deciphering the TGFβ pathway has uncovered a new signaling molecule, the Smads, and with this finding now gives us insights into how TGFβ-like signals are transmitted from outside the cell to the nucleus. As we learn more about how TGFβ regulates normal development, we also are gaining insights into diseases that are caused by mis-regulation or mutation of various components of the signaling pathways.
引用
收藏
页码：247 / 259
页数：12
相关论文
共 50 条
  • [41] TGFβ family signaling and development
    Jia, Shunji
    Meng, Anming
    [J]. DEVELOPMENT, 2021, 148 (05):
  • [42] Metabolomics and the Diagnosis of Human Diseases - A Guide to the Markers and Pathophysiological Pathways Affected
    Medina, S.
    Dominguez-Perles, R.
    Gil, J. I.
    Ferreres, F.
    Gil-Izquierdo, A.
    [J]. CURRENT MEDICINAL CHEMISTRY, 2014, 21 (07) : 823 - 848
  • [43] Human ESC Self-renewal Promoting microRNAs Induce Epithelial-Mesenchymal Transition in Hepatocytes by Controlling the PTEN and TGFβ Tumor Suppressor Signaling Pathways
    Jung, Christine J.
    Iyengar, Sushma
    Blahnik, Kimberly R.
    Jiang, Joy X.
    Tahimic, Candice
    Torok, Natalie J.
    White, Ralph W. de Vere
    Farnham, Peggy J.
    Zern, Mark
    [J]. MOLECULAR CANCER RESEARCH, 2012, 10 (07) : 979 - 991
  • [44] Effects of m6A modifications on signaling pathways in human cancer
    Liu, Fangyuan
    Su, Xiulan
    [J]. ONCOLOGY REPORTS, 2021, 45 (04)
  • [45] The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
    Dituri, Francesco
    Cossu, Carla
    Mancarella, Serena
    Giannelli, Gianluigi
    [J]. CELLS, 2019, 8 (10)
  • [46] Ubiquitin Ligases Involved in the Regulation of Wnt, TGF-β, and Notch Signaling Pathways and Their Roles in Mouse Development and Homeostasis
    Baloghova, Nikol
    Lidak, Tomas
    Cermak, Lukas
    [J]. GENES, 2019, 10 (10)
  • [47] H441 pulmonary epithelial cell mitogenic effects and signaling pathways in response to HGF and TGF-α
    Chess, PR
    Ryan, RM
    Finkelstein, JN
    [J]. EXPERIMENTAL LUNG RESEARCH, 1998, 24 (01) : 27 - 39
  • [48] RETRACTED: The Downregulation of MicroRNA-146a Modulates TGF-β Signaling Pathways Activity in Glioblastoma (Retracted Article)
    Lv, Shunzeng
    Sun, Bowen
    Dai, Congxin
    Shi, Ranran
    Zhou, Xingtong
    Lv, Wenyuan
    Zhong, Xiao
    Wang, Renzhi
    Ma, Wenbin
    [J]. MOLECULAR NEUROBIOLOGY, 2015, 52 (03) : 1257 - 1262
  • [49] Characterization of TGF-? signaling in a human organotypic skin model reveals that loss of TGF-?RII induces invasive tissue
    Ye, Zilu
    Kilic, Gulcan
    Dabelsteen, Sally
    Marinova, Irina N.
    Thofner, Jens F. B.
    Song, Ming
    Rudjord-Levann, Asha M.
    Bagdonaite, Ieva
    Vakhrushev, Sergey Y.
    Brakebusch, Cord H.
    Olsen, Jesper v
    Wandall, Hans H.
    [J]. SCIENCE SIGNALING, 2022, 15 (761)
  • [50] The immune suppressive function of transforming growth factor-β (TGF-β) in human diseases
    Sheng, Jingyi
    Chen, Weisan
    Zhu, Hong-Jian
    [J]. GROWTH FACTORS, 2015, 33 (02) : 92 - 101
12345