Clinical and laboratory profiles of systemic lupus erythematosus associated with Sjögren syndrome in China: a study of 542 patients

被引：0
作者：
Hai Feng Pan
Dong Qing Ye
Qian Wang
Wen Xian Li
Ning Zhang
Xiang Pei Li
Jian Hua Xu
Hong Dai
机构：
[1] Anhui Medical University,Department of Epidemiology and Biostatistics, School of Public Health
[2] Anhui Provincial Hospital,Department of Rheumatology
[3] Anhui Medical University,Department of Rheumatology, First Affiliated Hospital
来源：
Clinical Rheumatology | 2008年 / 27卷
关键词：
China; Sjögren syndrome; Systemic lupus erythematosus;
D O I：
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摘要：
This study aims to investigate the clinical and laboratory features of systemic lupus erythematosus (SLE) patients associated with Sjögren syndrome (SS) in China, as well as its similarities to and differences from SLE patients without SS. A group of 542 consecutive unselected SLE patients was recruited. Diagnosis of SLE was made according to 1997 revised American College of Rheumatology SLE criteria; SS was diagnosed using the American–European classification criteria. Clinical and laboratory parameters in SLE patients with SS (SLE-SS) were compared with those in SLE patients without SS (SLE-no SS). Overall, SS was identified in 35 SLE patients (6.5%); the onset of SS preceded the development of SLE in 17 of them (48.6%). Compared with the SLE-no SS group (35.8 ± 10.5 years), patients with SLE-SS (41.3 ± 11.6 years) were significantly older (P = 0.003), had a higher frequency of anti-Ro/SSA, anti-La/SSB, and anti-dsDNA antibodies, but had a significantly lower frequency of renal involvement. This study demonstrates that SLE-SS may be a subgroup of patients with characteristic clinical and laboratory features. To improve the treatment outcomes in SLE-SS patients, more specific treatment should be applied based on those factors.
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页码：339 / 343
页数：4
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  • [1] Scheinfeld N(2006)Sjogren syndrome and systemic lupus erythematosus are distinct conditions Dermatol Online J 12 4-891
  • [2] Manoussakis MN(2004)Sjogren’s syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjogren’s syndrome Arthritis Rheum 50 882-469
  • [3] Georgopoulou C(1959)Sjogren’s syndrome and systemic lupus erythematosus Br Med J 1 466-204
  • [4] Zintzaras E(1990)Sjogren’s syndrome in systemic lupus erythematosus J Rheumatol 17 201-930
  • [5] Heaton JM(2006)Clinical, serologic, and genetic profiles of patients with associated Sjogren’s syndrome and systemic lupus erythematosus Hum Immunol 67 924-2538
  • [6] Andonopoulos AP(2005)Association of systemic lupus erythematosus and Sjogren’s syndrome Orv Hetil 146 2533-608
  • [7] Skopouli FN(1999)The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes Arthritis Rheum 42 599-558
  • [8] Dimou GS(2002)Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American–European Consensus Group Ann Rheum Dis 61 554-121
  • [9] Szanto A(1997)Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus [letter] Arthritis Rheum 40 1725-376
  • [10] Szodoray P(1996)Assessment of the European classification criteria for Sjögren’s syndrome in a series of clinically defined cases: results of a prospective multicentre study. The European Study Group on Diagnostic Criteria for Sjögren’s Syndrome Ann Rheum Dis 55 116-234
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