Enhanced absorption of pour-on ivermectin formulation in rats by co-administration of the multidrug-resistant-reversing agent verapamil

被引：0

作者：

M. Alvinerie

J. Dupuy

C. Eeckhoutte

J. F. Sutra

机构：

[1] Laboratoire de Pharmacologie-Toxicologie,

[2] INRA,undefined

[3] 180,undefined

[4] chemin de Tournefeuille,undefined

[5] BP 3,undefined

[6] F-31931 Toulouse,undefined

[7] France e-mail: malviner@toulouse.inra.fr,undefined

[8] Fax: +33-5-61285310,undefined

来源：

Parasitology Research | 1999年 / 85卷

关键词：

Verapamil; Resistant Strain; Competitive Inhibitor; Ivermectin; Agent Verapamil;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The effect of verapamil, a multidrug-resistance (Mdr)-reversing agent on the absorption of a pour-on formulation of ivermectin was evaluated in rats. Absorption of ivermectin was effectively enhanced (40%) by the presence of verapamil, suggesting that absorption of ivermectin involves Mdr-P-glycoprotein and that verapamil should act as a competitive inhibitor for the transport and extrusion of ivermectin by P-glycoprotein. This hypothesis is consistent with other studies describing verapamil as a blocking agent of P-glycoprotein involved in the efflux of ivermectin in a resistant strain of Haemonchus contortus.

引用

页码：920 / 922

页数：2