Association of five candidate genes with fatty acid composition in Korean cattle

被引：0
作者：
D. Maharani
Y. Jung
W. Y. Jung
C. Jo
S. H. Ryoo
S. H. Lee
S. H. Yeon
J. H. Lee
机构：
[1] Chungnam National University,Department of Animal Science and Biotechnology, College of Agriculture and Life Sciences
[2] Gadjah Mada University,Faculty of Animal Science
[3] Livestock Research Institute,Animal Genomics and Bioinformatics Division
[4] Government of Chungcheongnam-Do,undefined
[5] Hanwoo Experiment Station,undefined
[6] National Institute of Animal Science,undefined
[7] RDA,undefined
[8] National Institute of Animal Science,undefined
[9] RDA,undefined
来源：
Molecular Biology Reports | 2012年 / 39卷
关键词：
FABP4; FASN; SCD; Fatty acid composition; Hanwoo; Muscle;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Fatty acid composition of meat is becoming more important due to consumer demand for high quality and healthy foods. The present study evaluated the associations of five candidate genes (FABP4, FASN, NR1H3, GH and SCD) with fatty acid composition in Korean cattle (Hanwoo). The g.3691G > A single nucleotide polymorphism (SNP) in the FABP4 gene had significant effects on high myristic acid (C14:0; P < 0.01) and palmitic (C16:0; P < 0.05) in animals having the GG genotype, and high arachidonic acid (C20:4; P < 0.05) in the AA genotype of Hanwoo. The FASN SNP at position g.17924G > A was also significantly associated with myristic acid (P < 0.01). In case of the SCD gene, a significant effect was only observed in myristoleic acid (C14:1; P < 0.01). However, SNPs in GH and NR1H3 genes showed no effects on fatty acid composition. The results indicate that SNPs in three candidate genes, FABP4, FASN and SCD, may be influential in breeding design for fatty acid composition in Hanwoo.
引用
收藏
页码：6113 / 6121
页数：8
相关论文
共 230 条
  • [1] Diana P(1998)The effect of sire breed on the melting point and fatty acid composition of subcutaneous fat in steers J Anim Sci 76 87-95
  • [2] Nichols PJ(2008)Fat deposition, fatty acid composition and meat quality: a review Meat Sci 78 343-358
  • [3] Thompson JM(2006)A quantitative trait locus for oleic fatty acid content on J Hered 97 535-537
  • [4] Wood JD(2004) chromosome 7 Genome Res 14 1424-1437
  • [5] Enser M(2008)A 1463 gene cattle-human comparative map with anchor points defined by human genome sequence coordinates BMC Genet 9 84-90
  • [6] Fisher AV(2006)Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese Black cattle Anim Genet 37 400-402
  • [7] Nute GR(2009)The bovine fatty acid binding protein 4 gene is significantly associated with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses Anim Genet 40 770-773
  • [8] Sheard PR(2008)A splice site single nucleotide polymorphism of the fatty acid binding protein 4 gene appears to be associated with intramuscular fat deposition in longissimus muscle in Australian cattle BMB Rep 41 29-34
  • [9] Richardson RI(2010)Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle Anim Genet 41 442-444
  • [10] Hughes SI(2008)Genetic polymorphisms of the bovine fatty acid binding protein 4 gene are significantly associated with marbling and carcass weight in Hanwoo (Korean Cattle) Anim Genet 39 62-70
12345678910