Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

被引：0
|
作者：
Sofia Konisti
Serafim Kiriakidis
Ewa M. Paleolog
机构：
[1] Charing Cross Hospital Campus,Department of Medicine
[2] Imperial College,Nuffield Department of Orthopedics
[3] Rheumatology and Musculoskeletal Sciences,undefined
[4] Kennedy Institute of Rheumatology,undefined
[5] University of Oxford,undefined
来源：
Nature Reviews Rheumatology | 2012年 / 8卷
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摘要：
The role of inflammation in rheumatoid arthritis (RA) is well characterized, but how hypoxia affects RA and the potential interplay between inflammation, angiogenesis and hypoxia in this disease is less defined. Here, the authors describe how hypoxia affects RA, in terms of both inflammation and angiogenesis, and provide insights as to how depleted oxygen levels affect the RA synovium. Potential therapies for RA that target angiogenesis will also be discussed.
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页码：153 / 162
页数：9
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