Human adipose tissue derived mesenchymal stem cells are resistant to several chemotherapeutic agents

被引：0
作者：
Wei Liang
Hailong Xia
Jing Li
Robert Chunhua Zhao
机构：
[1] The First Affiliated Hospital of Anhui Medical University,Department of Oncology, Center for Cell Therapy and Tissue Engineering
[2] Chinese Academy of Medical Science and Peking Union Medical College,Institute of Basic Medical Science and School of Basic Medicine, Center of Excellence in Tissue Engineering
来源：
Cytotechnology | 2011年 / 63卷
关键词：
Adipose tissue; MSCs; Chemoresistance; Cisplatin; Vincristine; Camptothecin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Human adipose derived mesenchymal stem cells (ADMSCs) are multipotential stem cells, originated from the vascular stromal compartment of fat tissues which can be used as an alternative cell source for many different cell therapies. However, their response to chemotherapeutic agants remains unknown. Here we assessed the acute direct effects of individual chemotherapeutic drug on ADMSCs. Using an in vitro culture system, the response of ADMSCs to the three chemotherapeutic agents cisplatin, comptothecin and vincristine was determined in comparison with that of testicular germ cell tumour (TGCT) cell line. The recovery of cell numbers following exposure to chemotherapeutic agents were also evaluated. Our results showed that human ADMSCs were resistant to chemo-therapeutic agents which are commonly used in clinic, the full recovery was seen respectively in ADMSCs after the drug treatment. Moreover, ADMSCs maintained their stem cell characteristics in vitro after the exposure to all chemotherapeutic agents.
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页码：523 / 530
页数：7
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