Low density lipoprotein (LDL), atherosclerosis and antioxidants

被引：0

作者：

Ryu B.H. ^{[1
]}

机构：

[1] Department of Food Science and Biotechnology, Kyungsung University

来源：

Biotechnology and Bioprocess Engineering | 2000年 / 5卷 / 5期

关键词：

Antioxidant; Atherosclerosis; Low density lipoprotein (LDL);

D O I：

10.1007/BF02942205

中图分类号：

学科分类号：

摘要：

A crucial and causative role in the pathogenesis of atherosclerosis is believed to be the oxidative modification of low density lipoprotein (LDL). The oxidation of LDL involves released free radical driven lipid peroxidation. Several lines of evidence support the role of oxidized LDL in atherogenesis. Epidemiologic studies have demonstrated an association between an increased intake of dietary antioxidant vitamins, such as vitamin E and vitamin C and reduced morbidity and mortality from coronary artery diseases. It is thus hypothesized that dietary antioxidants may help prevent the development and progression of atherosclerosis. The oxidation of LDL has been shown to be reduced by antioxidants, and, in animal models, improved antioxidants may offer possibilities for the prevention of atherosclerosis. The results of several on going long randomized intervention trials will provide valuable information on the efficacy and safety of improved antioxidants in the prevention of atherosclerosis. This review a evaluates current literature involving antioxidants and vascular disease, with a particular focus on the potential mechanisms.

引用

页码：313 / 319

页数：6

共 37 条

[21]

Riemersas R.A., Wood D.A., Macintyre C.C.A., Elton R.A., Gey K.E., Oliver M.E., Risk of angina pectoris and plasma concentrations of vitamins A, C, and e and carotene, Lancet, 337, pp. 1-6, (1991)

[22]

Trevor-Me L., Chait A., Raines W., Ross R., The influence of oxidatirely modified low density lipo-proteins on expression of latelet-derived growth factor by human monocyte-derived macrophages, J. Biol. Chem., 226, pp. 13901-13901, (1991)

[23]

Singh R.B., Niaz M.A., Ghosh S., Rastogi S.S., Effect on mortality and reinfarction of adding fruits and vegetables to a prudent diet in the Indian experiment of infact Survival, J. Am. Coll. Nutr., 12, pp. 225-261, (1993)

[24]

Stampfer M.J., Hennekens C.H., Manson J.E., Colditz G.A., Rosner B., Willett W.C., Vitamin e consumption and the risk of coronary disease in women, N. Engl. J. Med., 328, pp. 1444-1449, (1993)

[25]

Rimm E.B., Stampfer M.J., Ascherio A., Giovannucci E., Colditz G.A., Willett W.C., Vitamin E consumption and the risk of coronary heart disease in men, N. Engl. J. Med., 328, pp. 1450-1456, (1993)

[26]

Losonczy K.G., Harris T.B., Havlik R.J., Vitamin E and vitamin C supplement use and risk of all-cause and coronary beart disease mortality in older persons: The established populations for epidemiologic studies of the elderly, Am. J. Clin. Nutr., 64, pp. 190-196, (1996)

[27]

Stephens N.G., Parsons A., Schofield P.M., Kelly E., Cheeseman K., Mitecenson M.J., Randomized controlled trial of vitamin e in patients with coronary disease: Cambridge heart antioxidant study (GHAO), Lancet, 347, pp. 781-786, (1996)

[28]

Jialal I., Scaccini C., Antioxidants and atherosclerosis, Curr. Opin. Lipidol., 3, pp. 324-328, (1992)

[29]

Ferns G.A.A., Forster L., Stewart-Lee A., Konneh M., Nourooz-Zadeh J., Anggard E.E., Probucol inhibits neointimal thickening and macrophage accumulation after balloon injury in the cholesterol-fed rabbit, Proc. Natl. Acad. Sci. USA, 89, pp. 11312-11316, (1992)

[30]

Freyschuss A., Stiko-Rahm A., Swedenborg J., Henriksson P., Bjorkhem I., Berglund L., Nilsson J., Anti-oxidant treatment inhibits the development of intimal thickening after balloon injury of the aorta in hypercholesterolemic rabbits, J Clin. Invest., 91, pp. 1282-1288, (1993)

← 1 2 3 4 →